Comparison of the inhibitory effects of cilostazol, acetylsalicylic acid and ticlopidine on platelet functions ex vivo. Randomized, double-blind cross-over study

Y. Ikeda, M. Kikuchi, H. Murakami, K. Satoh, M. Murata, K. Watanabe, Y. Ando

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Abstract

A randomized double-blind cross-over study was conducted to determine the inhibitory effects of acetylsalicylic acid (ASA), ticlopidine (TP) and cilostazol (OPC-13013; in the following briefly called CS), a new antithrombotic agent on platelet functions ex vivo. Nine patients with cerebral thrombosis were enrolled in this study. Patients were given each of the three drugs for one week in a complete cross-over design according to a randomization schedule, followed by a wash-out period with a placebo for one week. It was found that CS and TP significantly inhibited platelet aggregation induced by ADP. Collagen- and arachidonic acid-induced platelet aggregation was all inhibited by CS, TP and ASA. Duncan's multiple range test to compare the anti-platelet effects of the three drugs revealed that: CS > ASA and TP > ASA in inhibiting ADP-induced platelet aggregation and CS > TP and ASA > TP in inhibiting arachidonic acid-induced platelet aggregation. These results may suggest that CS is superior to ASA and TP in inhibiting platelet aggregation ex vivo.

Original languageEnglish
Pages (from-to)563-566
Number of pages4
JournalArzneimittel-Forschung/Drug Research
Volume37
Issue number5
Publication statusPublished - 1987 Jul 6
Externally publishedYes

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ASJC Scopus subject areas

  • Drug Discovery

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