Complanine, an inflammation-inducing substance isolated from the marine fireworm Eurythoe complanata

Kazuhiko Nakamura, Yu Tachikawa, Makoto Kitamura, Osamu Ohno, Masami Suganuma, Daisuke Uemura

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

The marine fireworm, Eurythoe complanata, is known as a dangerous animal for humans because it induces skin inflammation through its small setae. Here, the inflammation-inducing substance was successfully isolated from the whole body using a methanolic extraction, and the inflammatory activity was determined using a bioassay. The structure was spectroscopically revealed to be a trimethylammonium with an unsaturated carbon chain and was named complanine. Complanine enhanced PKC activity in combination with TPA in vitro. This may explain the molecular mechanism behind its inflammation-inducing activity.

Original languageEnglish
Pages (from-to)2058-2060
Number of pages3
JournalOrganic and Biomolecular Chemistry
Volume6
Issue number12
DOIs
Publication statusPublished - 2008

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Inflammation
Bioassay
Sensilla
Skin
bioassay
Animals
Carbon
Biological Assay
animals
carbon
complanine
In Vitro Techniques

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Chemistry(all)

Cite this

Complanine, an inflammation-inducing substance isolated from the marine fireworm Eurythoe complanata. / Nakamura, Kazuhiko; Tachikawa, Yu; Kitamura, Makoto; Ohno, Osamu; Suganuma, Masami; Uemura, Daisuke.

In: Organic and Biomolecular Chemistry, Vol. 6, No. 12, 2008, p. 2058-2060.

Research output: Contribution to journalArticle

Nakamura, K, Tachikawa, Y, Kitamura, M, Ohno, O, Suganuma, M & Uemura, D 2008, 'Complanine, an inflammation-inducing substance isolated from the marine fireworm Eurythoe complanata', Organic and Biomolecular Chemistry, vol. 6, no. 12, pp. 2058-2060. https://doi.org/10.1039/b803107j
Nakamura, Kazuhiko ; Tachikawa, Yu ; Kitamura, Makoto ; Ohno, Osamu ; Suganuma, Masami ; Uemura, Daisuke. / Complanine, an inflammation-inducing substance isolated from the marine fireworm Eurythoe complanata. In: Organic and Biomolecular Chemistry. 2008 ; Vol. 6, No. 12. pp. 2058-2060.
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