Complanine, an inflammation-inducing substance isolated from the marine fireworm Eurythoe complanata

Kazuhiko Nakamura, Yu Tachikawa, Makoto Kitamura, Osamu Ohno, Masami Suganuma, Daisuke Uemura

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

The marine fireworm, Eurythoe complanata, is known as a dangerous animal for humans because it induces skin inflammation through its small setae. Here, the inflammation-inducing substance was successfully isolated from the whole body using a methanolic extraction, and the inflammatory activity was determined using a bioassay. The structure was spectroscopically revealed to be a trimethylammonium with an unsaturated carbon chain and was named complanine. Complanine enhanced PKC activity in combination with TPA in vitro. This may explain the molecular mechanism behind its inflammation-inducing activity.

Original languageEnglish
Pages (from-to)2058-2060
Number of pages3
JournalOrganic and Biomolecular Chemistry
Volume6
Issue number12
DOIs
Publication statusPublished - 2008 Jun 17

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Fingerprint Dive into the research topics of 'Complanine, an inflammation-inducing substance isolated from the marine fireworm Eurythoe complanata'. Together they form a unique fingerprint.

  • Cite this