Complete clinical and pathological response to mFOLFOX6 neoadjuvant chemotherapy in a case of advanced rectal cancer

Katsuaki Mori, Hiroyuki Kikunaga, Atsushi Morisue, Koji Fujita, Kei Ichi Ishikawa, Tadayuki Sakuragawa, Koichiro Kumai, Hiroshi Miura, Shuji Mikami

Research output: Contribution to journalArticle

Abstract

The patient was a 78-year-old woman with a chief complaint of abdominal bloating and constipation who was referred to us and was examined for an AV 12-15 cm, circumferential type 2 rectal cancer. The pathological diagnosis was adenocarcinoma (tub1+tub2). T4 and N2 were suspected based on the CT findings, and because the CEA value was high, the patient was treated with 7 courses of mFOLFOX6 neoadjuvant chemotherapy followed by salvage surgery (low anterior resection+D3). Examination of the surgical specimen revealed chronic inflammatory cell infiltration, including histiocytes accompanied by ulceration, and fibrosis was observed down to SS. No viable cancer cells were detected, and the tumor response was evaluated as a pathological CR. mFOLFOX6 appeared to be effective as neoadjuvant chemotherapy for advanced rectal cancer.

Original languageEnglish
Pages (from-to)679-682
Number of pages4
JournalJapanese Journal of Cancer and Chemotherapy
Volume39
Issue number4
Publication statusPublished - 2012 Apr

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Rectal Neoplasms
Drug Therapy
Histiocytes
Constipation
Neoplasms
Adenocarcinoma
Fibrosis

Keywords

  • Advanced rectal cancer
  • mFOLFOX6
  • Pathological CR
  • Postoperative adjuvant chemotherapy

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Complete clinical and pathological response to mFOLFOX6 neoadjuvant chemotherapy in a case of advanced rectal cancer. / Mori, Katsuaki; Kikunaga, Hiroyuki; Morisue, Atsushi; Fujita, Koji; Ishikawa, Kei Ichi; Sakuragawa, Tadayuki; Kumai, Koichiro; Miura, Hiroshi; Mikami, Shuji.

In: Japanese Journal of Cancer and Chemotherapy, Vol. 39, No. 4, 04.2012, p. 679-682.

Research output: Contribution to journalArticle

Mori, K, Kikunaga, H, Morisue, A, Fujita, K, Ishikawa, KI, Sakuragawa, T, Kumai, K, Miura, H & Mikami, S 2012, 'Complete clinical and pathological response to mFOLFOX6 neoadjuvant chemotherapy in a case of advanced rectal cancer', Japanese Journal of Cancer and Chemotherapy, vol. 39, no. 4, pp. 679-682.
Mori, Katsuaki ; Kikunaga, Hiroyuki ; Morisue, Atsushi ; Fujita, Koji ; Ishikawa, Kei Ichi ; Sakuragawa, Tadayuki ; Kumai, Koichiro ; Miura, Hiroshi ; Mikami, Shuji. / Complete clinical and pathological response to mFOLFOX6 neoadjuvant chemotherapy in a case of advanced rectal cancer. In: Japanese Journal of Cancer and Chemotherapy. 2012 ; Vol. 39, No. 4. pp. 679-682.
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