TY - JOUR
T1 - Complete clinical and pathological response to mFOLFOX6 neoadjuvant chemotherapy in a case of advanced rectal cancer
AU - Mori, Katsuaki
AU - Kikunaga, Hiroyuki
AU - Morisue, Atsushi
AU - Fujita, Koji
AU - Ishikawa, Kei Ichi
AU - Sakuragawa, Tadayuki
AU - Kumai, Koichiro
AU - Miura, Hiroshi
AU - Mikami, Shuji
PY - 2012/4
Y1 - 2012/4
N2 - The patient was a 78-year-old woman with a chief complaint of abdominal bloating and constipation who was referred to us and was examined for an AV 12-15 cm, circumferential type 2 rectal cancer. The pathological diagnosis was adenocarcinoma (tub1+tub2). T4 and N2 were suspected based on the CT findings, and because the CEA value was high, the patient was treated with 7 courses of mFOLFOX6 neoadjuvant chemotherapy followed by salvage surgery (low anterior resection+D3). Examination of the surgical specimen revealed chronic inflammatory cell infiltration, including histiocytes accompanied by ulceration, and fibrosis was observed down to SS. No viable cancer cells were detected, and the tumor response was evaluated as a pathological CR. mFOLFOX6 appeared to be effective as neoadjuvant chemotherapy for advanced rectal cancer.
AB - The patient was a 78-year-old woman with a chief complaint of abdominal bloating and constipation who was referred to us and was examined for an AV 12-15 cm, circumferential type 2 rectal cancer. The pathological diagnosis was adenocarcinoma (tub1+tub2). T4 and N2 were suspected based on the CT findings, and because the CEA value was high, the patient was treated with 7 courses of mFOLFOX6 neoadjuvant chemotherapy followed by salvage surgery (low anterior resection+D3). Examination of the surgical specimen revealed chronic inflammatory cell infiltration, including histiocytes accompanied by ulceration, and fibrosis was observed down to SS. No viable cancer cells were detected, and the tumor response was evaluated as a pathological CR. mFOLFOX6 appeared to be effective as neoadjuvant chemotherapy for advanced rectal cancer.
KW - Advanced rectal cancer
KW - Pathological CR
KW - Postoperative adjuvant chemotherapy
KW - mFOLFOX6
UR - http://www.scopus.com/inward/record.url?scp=84862560726&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84862560726&partnerID=8YFLogxK
M3 - Article
C2 - 22504702
AN - SCOPUS:84862560726
SN - 0385-0684
VL - 39
SP - 679
EP - 682
JO - Japanese Journal of Cancer and Chemotherapy
JF - Japanese Journal of Cancer and Chemotherapy
IS - 4
ER -
