Complete response to ethnylestradiol prolonged for almost two years in patients with castration-resistant prostate cancer

Hiroshi Hongo, Takeo Kosaka, Mototsugu Oya

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Abstract

An 80-year-old man with an elevated prostate-specific antigen (PSA) level of 120 ng/mL) presented to the hospital in February 2011. A prostate needle biopsy was performed, and pathological examination revealed prostatic adenocarcinoma. The Gleason score was 4+5=9. Computed tomography revealed metastases of the pelvic lymph nodes. Combined androgen blockade was started. The PSA concentration decreased to 1.68 ng/mL, but started increasing again in August 2012 to 6.08 ng/mL. Although bicalutamide was discontinued due to antiandrogen withdrawal syndrome, the PSA concentration increased even more. The PSA concentration reached 21.62 ng/mL in September 2012, at which time ethnylestradiol was started. The PSA concentration decreased again and has remained below the limit of sensitivity for almost 2 years. To our knowledge, this is first case report describing a complete response to ethnylestradiol that lasted for almost 2 years in a patient with castration-resistant prostate cancer.

Original languageEnglish
Pages (from-to)e921-e923
JournalJournal of the Canadian Urological Association
Volume8
Issue number11-12 DECEMBER
DOIs
Publication statusPublished - 2014 Dec 1

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Keywords

  • Androgen
  • Androgen receptor
  • Estrogen
  • Ethnylestradiol
  • Prostate cancer
  • Prostate specific antigen

ASJC Scopus subject areas

  • Oncology
  • Urology

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