Complete response to paclitaxel, ifosfamide, and cisplatin therapy in a case of ovarian ependymoma

Makiko Hino, Yusuke Kobayashi, Michiko Wada, Yoshihisa Hattori, Takashi Kurahasi, Hiroyuki Nakagawa

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

There are many reports on paclitaxel, ifosfamide, and cisplatin (TIP) therapy, following standard bleomycin, etoposide, and cisplatin (BEP) therapy, for salvage treatment of testicular malignant germ cell tumors, but there are no reports on its use for ovarian malignant tumors. We report here that a patient with primary ependymoma of the ovary, who was resistant to BEP therapy, achieved a complete response to a combined therapy, including TIP therapy as the second-line chemotherapy and surgery. This important case, combined with published studies, suggests that TIP therapy is effective for both testicular and ovarian malignant tumors and indicates that TIP therapy can be used as an effective second-line therapy for malignant tumors resistant to BEP therapy.

Original languageEnglish
Pages (from-to)1613-1617
Number of pages5
JournalJournal of Obstetrics and Gynaecology Research
Volume42
Issue number11
DOIs
Publication statusPublished - 2016 Nov 1

Keywords

  • bleomycin, etoposide, and cisplatin
  • ependymoma
  • malignant germ cell tumors
  • paclitaxel, ifosfamide, and cisplatin
  • salvage

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

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