Complex-type chromosomal exchanges in blood lymphocytes during radiation therapy correlate with acute toxicity

Shigeru Yamada, Marco Durante, Koichi Ando, Yoshiya Furusawa, Tetsuya Kawata, Hideyuki Majima, Hirohiko Tsujii

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The new method of chemical-induced premature chromosome condensation combined with fluorescence in situ hybridization was used to analyze chromosomal damage in peripheral blood mononuclear lymphocytes of patients undergoing radiation treatment for esophageal cancer with high-energy X-rays or accelerated carbon ions at the National Institute of Radiological Sciences (Chiba, Japan). Total number of aberrant cells correlated with radiation field size, but no correlation was found with acute toxicity. A high frequency of complex-type exchanges were also recorded. This aberration type presented a high individual variability, and correlated well with the acute morbidity. Cytogenetic analysis by interphase chromosome painting is proposed as a useful tool for monitoring normal tissue effects during radiotherapy. (C) 2000 Elsevier Science Ireland Ltd.

Original languageEnglish
Pages (from-to)215-221
Number of pages7
JournalCancer Letters
Volume150
Issue number2
DOIs
Publication statusPublished - 2000 Mar 31

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Keywords

  • Chromosomal aberrations
  • Complex exchanges
  • Morbidity
  • Oesophageal cancer
  • Predictive assay
  • Radiotherapy

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Yamada, S., Durante, M., Ando, K., Furusawa, Y., Kawata, T., Majima, H., & Tsujii, H. (2000). Complex-type chromosomal exchanges in blood lymphocytes during radiation therapy correlate with acute toxicity. Cancer Letters, 150(2), 215-221. https://doi.org/10.1016/S0304-3835(99)00405-X