Complications after spinal fixation surgery for osteoporotic vertebral collapse with neurological deficits: Japan Association of Spine Surgeons with ambition multicenter study

Yusuke Sakai, Takashi Kaito, Shota Takenaka, Tomoya Yamashita, Takahiro Makino, Naobumi Hosogane, Kenya Nojiri, Satoshi Suzuki, Eijiro Okada, Kota Watanabe, Haruki Funao, Norihiro Isogai, Seiji Ueda, Tomohiro Hikata, Yuta Shiono, Kei Watanabe, Keiichi Katsumi, Hiroyasu Fujiwara, Yukitaka Nagamoto, Hidetomi TeraiKoji Tamai, Yuji Matsuoka, Hidekazu Suzuki, Hirosuke Nishimura, Atsushi Tagami, Shuta Yamada, Shinji Adachi, Seiji Ohtori, Sumihisa Orita, Takeo Furuya, Toshitaka Yoshii, Shuta Ushio, Gen Inoue, Masayuki Miyagi, Wataru Saito, Shiro Imagama, Kei Ando, Daisuke Sakai, Tadashi Nukaga, Katsuhito Kiyasu, Atsushi Kimura, Hirokazu Inoue, Atsushi Nakano, Katsumi Harimaya, Toshio Doi, Kenichi Kawaguchi, Nobuhiko Yokoyama, Hidekazu Oishi, Shota Ikegami, Toshimasa Futatsugi, Masayuki Shimizu, Kenichiro Kakutani, Takashi Yurube, Masashi Oshima, Hiroshi Uei, Yasuchika Aoki, Masahiko Takahata, Akira Iwata, Shoji Seki, Hideki Murakami, Katsuhito Yoshioka, Hirooki Endo, Michio Hongo, Kazuyoshi Nakanishi, Tetsuya Abe, Toshinori Tsukanishi, Ken Ishii

Research output: Contribution to journalArticle

Abstract

Background: There have been few reports on the incidence and risk factors of the complications after spinal fixation surgery for osteoporotic vertebral collapse (OVC) with neurological deficits. This study aimed to identify the incidence and risk factors of the complications after OVC surgery. Methods: In this retrospective multicenter study, a total of 403 patients (314 women and 89 men; mean age 73.8 years) who underwent spinal fixation surgery for OVC with neurological deficits between 2005 and 2014 were enrolled. Data on patient demographics were collected, including age, sex, body mass index, smoking, steroid use, medical comorbidities, and surgical procedures. All postoperative complications that occurred within 6 weeks were recorded. Patients were classified into two groups, namely, complication group and no complication group, and risk factors for postoperative complications were investigated by univariate and multivariate analyses. Results: Postoperative complications occurred in 57 patients (14.1%), and the most common complication was delirium (5.7%). In the univariate analysis, the complication group was found to be older (p = 0.039) and predominantly male (p = 0.049), with higher occurrence rate of liver disease (p = 0.001) and Parkinson's disease (p = 0.039) compared with the no-complication group. In the multivariate analysis, the significant independent risk factors were age (p = 0.021; odds ratio [OR] 1.051, 95% confidence interval [CI] 1.007–1.097), liver disease (p < 0.001; OR 8.993, 95% CI 2.882–28.065), and Parkinson's disease (p = 0.009; OR 3.636, 95% CI 1.378–9.599). Conclusions: Complications after spinal fixation surgery for OVC with neurological deficits occurred in 14.1%. Age, liver disease, and Parkinson's disease were demonstrated to be independent risk factors for postoperative complications.

Original languageEnglish
Pages (from-to)985-990
Number of pages6
JournalJournal of Orthopaedic Science
Volume24
Issue number6
DOIs
Publication statusPublished - 2019 Nov

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Multicenter Studies
Japan
Spine
Parkinson Disease
Liver Diseases
Odds Ratio
Confidence Intervals
Multivariate Analysis
Delirium
Incidence
Comorbidity
Body Mass Index
Retrospective Studies
Smoking
Steroids
Demography
Surgeons

ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine

Cite this

Complications after spinal fixation surgery for osteoporotic vertebral collapse with neurological deficits : Japan Association of Spine Surgeons with ambition multicenter study. / Sakai, Yusuke; Kaito, Takashi; Takenaka, Shota; Yamashita, Tomoya; Makino, Takahiro; Hosogane, Naobumi; Nojiri, Kenya; Suzuki, Satoshi; Okada, Eijiro; Watanabe, Kota; Funao, Haruki; Isogai, Norihiro; Ueda, Seiji; Hikata, Tomohiro; Shiono, Yuta; Watanabe, Kei; Katsumi, Keiichi; Fujiwara, Hiroyasu; Nagamoto, Yukitaka; Terai, Hidetomi; Tamai, Koji; Matsuoka, Yuji; Suzuki, Hidekazu; Nishimura, Hirosuke; Tagami, Atsushi; Yamada, Shuta; Adachi, Shinji; Ohtori, Seiji; Orita, Sumihisa; Furuya, Takeo; Yoshii, Toshitaka; Ushio, Shuta; Inoue, Gen; Miyagi, Masayuki; Saito, Wataru; Imagama, Shiro; Ando, Kei; Sakai, Daisuke; Nukaga, Tadashi; Kiyasu, Katsuhito; Kimura, Atsushi; Inoue, Hirokazu; Nakano, Atsushi; Harimaya, Katsumi; Doi, Toshio; Kawaguchi, Kenichi; Yokoyama, Nobuhiko; Oishi, Hidekazu; Ikegami, Shota; Futatsugi, Toshimasa; Shimizu, Masayuki; Kakutani, Kenichiro; Yurube, Takashi; Oshima, Masashi; Uei, Hiroshi; Aoki, Yasuchika; Takahata, Masahiko; Iwata, Akira; Seki, Shoji; Murakami, Hideki; Yoshioka, Katsuhito; Endo, Hirooki; Hongo, Michio; Nakanishi, Kazuyoshi; Abe, Tetsuya; Tsukanishi, Toshinori; Ishii, Ken.

In: Journal of Orthopaedic Science, Vol. 24, No. 6, 11.2019, p. 985-990.

Research output: Contribution to journalArticle

Sakai, Y, Kaito, T, Takenaka, S, Yamashita, T, Makino, T, Hosogane, N, Nojiri, K, Suzuki, S, Okada, E, Watanabe, K, Funao, H, Isogai, N, Ueda, S, Hikata, T, Shiono, Y, Watanabe, K, Katsumi, K, Fujiwara, H, Nagamoto, Y, Terai, H, Tamai, K, Matsuoka, Y, Suzuki, H, Nishimura, H, Tagami, A, Yamada, S, Adachi, S, Ohtori, S, Orita, S, Furuya, T, Yoshii, T, Ushio, S, Inoue, G, Miyagi, M, Saito, W, Imagama, S, Ando, K, Sakai, D, Nukaga, T, Kiyasu, K, Kimura, A, Inoue, H, Nakano, A, Harimaya, K, Doi, T, Kawaguchi, K, Yokoyama, N, Oishi, H, Ikegami, S, Futatsugi, T, Shimizu, M, Kakutani, K, Yurube, T, Oshima, M, Uei, H, Aoki, Y, Takahata, M, Iwata, A, Seki, S, Murakami, H, Yoshioka, K, Endo, H, Hongo, M, Nakanishi, K, Abe, T, Tsukanishi, T & Ishii, K 2019, 'Complications after spinal fixation surgery for osteoporotic vertebral collapse with neurological deficits: Japan Association of Spine Surgeons with ambition multicenter study', Journal of Orthopaedic Science, vol. 24, no. 6, pp. 985-990. https://doi.org/10.1016/j.jos.2019.08.015
Sakai, Yusuke ; Kaito, Takashi ; Takenaka, Shota ; Yamashita, Tomoya ; Makino, Takahiro ; Hosogane, Naobumi ; Nojiri, Kenya ; Suzuki, Satoshi ; Okada, Eijiro ; Watanabe, Kota ; Funao, Haruki ; Isogai, Norihiro ; Ueda, Seiji ; Hikata, Tomohiro ; Shiono, Yuta ; Watanabe, Kei ; Katsumi, Keiichi ; Fujiwara, Hiroyasu ; Nagamoto, Yukitaka ; Terai, Hidetomi ; Tamai, Koji ; Matsuoka, Yuji ; Suzuki, Hidekazu ; Nishimura, Hirosuke ; Tagami, Atsushi ; Yamada, Shuta ; Adachi, Shinji ; Ohtori, Seiji ; Orita, Sumihisa ; Furuya, Takeo ; Yoshii, Toshitaka ; Ushio, Shuta ; Inoue, Gen ; Miyagi, Masayuki ; Saito, Wataru ; Imagama, Shiro ; Ando, Kei ; Sakai, Daisuke ; Nukaga, Tadashi ; Kiyasu, Katsuhito ; Kimura, Atsushi ; Inoue, Hirokazu ; Nakano, Atsushi ; Harimaya, Katsumi ; Doi, Toshio ; Kawaguchi, Kenichi ; Yokoyama, Nobuhiko ; Oishi, Hidekazu ; Ikegami, Shota ; Futatsugi, Toshimasa ; Shimizu, Masayuki ; Kakutani, Kenichiro ; Yurube, Takashi ; Oshima, Masashi ; Uei, Hiroshi ; Aoki, Yasuchika ; Takahata, Masahiko ; Iwata, Akira ; Seki, Shoji ; Murakami, Hideki ; Yoshioka, Katsuhito ; Endo, Hirooki ; Hongo, Michio ; Nakanishi, Kazuyoshi ; Abe, Tetsuya ; Tsukanishi, Toshinori ; Ishii, Ken. / Complications after spinal fixation surgery for osteoporotic vertebral collapse with neurological deficits : Japan Association of Spine Surgeons with ambition multicenter study. In: Journal of Orthopaedic Science. 2019 ; Vol. 24, No. 6. pp. 985-990.
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title = "Complications after spinal fixation surgery for osteoporotic vertebral collapse with neurological deficits: Japan Association of Spine Surgeons with ambition multicenter study",
abstract = "Background: There have been few reports on the incidence and risk factors of the complications after spinal fixation surgery for osteoporotic vertebral collapse (OVC) with neurological deficits. This study aimed to identify the incidence and risk factors of the complications after OVC surgery. Methods: In this retrospective multicenter study, a total of 403 patients (314 women and 89 men; mean age 73.8 years) who underwent spinal fixation surgery for OVC with neurological deficits between 2005 and 2014 were enrolled. Data on patient demographics were collected, including age, sex, body mass index, smoking, steroid use, medical comorbidities, and surgical procedures. All postoperative complications that occurred within 6 weeks were recorded. Patients were classified into two groups, namely, complication group and no complication group, and risk factors for postoperative complications were investigated by univariate and multivariate analyses. Results: Postoperative complications occurred in 57 patients (14.1{\%}), and the most common complication was delirium (5.7{\%}). In the univariate analysis, the complication group was found to be older (p = 0.039) and predominantly male (p = 0.049), with higher occurrence rate of liver disease (p = 0.001) and Parkinson's disease (p = 0.039) compared with the no-complication group. In the multivariate analysis, the significant independent risk factors were age (p = 0.021; odds ratio [OR] 1.051, 95{\%} confidence interval [CI] 1.007–1.097), liver disease (p < 0.001; OR 8.993, 95{\%} CI 2.882–28.065), and Parkinson's disease (p = 0.009; OR 3.636, 95{\%} CI 1.378–9.599). Conclusions: Complications after spinal fixation surgery for OVC with neurological deficits occurred in 14.1{\%}. Age, liver disease, and Parkinson's disease were demonstrated to be independent risk factors for postoperative complications.",
author = "Yusuke Sakai and Takashi Kaito and Shota Takenaka and Tomoya Yamashita and Takahiro Makino and Naobumi Hosogane and Kenya Nojiri and Satoshi Suzuki and Eijiro Okada and Kota Watanabe and Haruki Funao and Norihiro Isogai and Seiji Ueda and Tomohiro Hikata and Yuta Shiono and Kei Watanabe and Keiichi Katsumi and Hiroyasu Fujiwara and Yukitaka Nagamoto and Hidetomi Terai and Koji Tamai and Yuji Matsuoka and Hidekazu Suzuki and Hirosuke Nishimura and Atsushi Tagami and Shuta Yamada and Shinji Adachi and Seiji Ohtori and Sumihisa Orita and Takeo Furuya and Toshitaka Yoshii and Shuta Ushio and Gen Inoue and Masayuki Miyagi and Wataru Saito and Shiro Imagama and Kei Ando and Daisuke Sakai and Tadashi Nukaga and Katsuhito Kiyasu and Atsushi Kimura and Hirokazu Inoue and Atsushi Nakano and Katsumi Harimaya and Toshio Doi and Kenichi Kawaguchi and Nobuhiko Yokoyama and Hidekazu Oishi and Shota Ikegami and Toshimasa Futatsugi and Masayuki Shimizu and Kenichiro Kakutani and Takashi Yurube and Masashi Oshima and Hiroshi Uei and Yasuchika Aoki and Masahiko Takahata and Akira Iwata and Shoji Seki and Hideki Murakami and Katsuhito Yoshioka and Hirooki Endo and Michio Hongo and Kazuyoshi Nakanishi and Tetsuya Abe and Toshinori Tsukanishi and Ken Ishii",
year = "2019",
month = "11",
doi = "10.1016/j.jos.2019.08.015",
language = "English",
volume = "24",
pages = "985--990",
journal = "Journal of Orthopaedic Science",
issn = "0949-2658",
publisher = "Springer Japan",
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TY - JOUR

T1 - Complications after spinal fixation surgery for osteoporotic vertebral collapse with neurological deficits

T2 - Japan Association of Spine Surgeons with ambition multicenter study

AU - Sakai, Yusuke

AU - Kaito, Takashi

AU - Takenaka, Shota

AU - Yamashita, Tomoya

AU - Makino, Takahiro

AU - Hosogane, Naobumi

AU - Nojiri, Kenya

AU - Suzuki, Satoshi

AU - Okada, Eijiro

AU - Watanabe, Kota

AU - Funao, Haruki

AU - Isogai, Norihiro

AU - Ueda, Seiji

AU - Hikata, Tomohiro

AU - Shiono, Yuta

AU - Watanabe, Kei

AU - Katsumi, Keiichi

AU - Fujiwara, Hiroyasu

AU - Nagamoto, Yukitaka

AU - Terai, Hidetomi

AU - Tamai, Koji

AU - Matsuoka, Yuji

AU - Suzuki, Hidekazu

AU - Nishimura, Hirosuke

AU - Tagami, Atsushi

AU - Yamada, Shuta

AU - Adachi, Shinji

AU - Ohtori, Seiji

AU - Orita, Sumihisa

AU - Furuya, Takeo

AU - Yoshii, Toshitaka

AU - Ushio, Shuta

AU - Inoue, Gen

AU - Miyagi, Masayuki

AU - Saito, Wataru

AU - Imagama, Shiro

AU - Ando, Kei

AU - Sakai, Daisuke

AU - Nukaga, Tadashi

AU - Kiyasu, Katsuhito

AU - Kimura, Atsushi

AU - Inoue, Hirokazu

AU - Nakano, Atsushi

AU - Harimaya, Katsumi

AU - Doi, Toshio

AU - Kawaguchi, Kenichi

AU - Yokoyama, Nobuhiko

AU - Oishi, Hidekazu

AU - Ikegami, Shota

AU - Futatsugi, Toshimasa

AU - Shimizu, Masayuki

AU - Kakutani, Kenichiro

AU - Yurube, Takashi

AU - Oshima, Masashi

AU - Uei, Hiroshi

AU - Aoki, Yasuchika

AU - Takahata, Masahiko

AU - Iwata, Akira

AU - Seki, Shoji

AU - Murakami, Hideki

AU - Yoshioka, Katsuhito

AU - Endo, Hirooki

AU - Hongo, Michio

AU - Nakanishi, Kazuyoshi

AU - Abe, Tetsuya

AU - Tsukanishi, Toshinori

AU - Ishii, Ken

PY - 2019/11

Y1 - 2019/11

N2 - Background: There have been few reports on the incidence and risk factors of the complications after spinal fixation surgery for osteoporotic vertebral collapse (OVC) with neurological deficits. This study aimed to identify the incidence and risk factors of the complications after OVC surgery. Methods: In this retrospective multicenter study, a total of 403 patients (314 women and 89 men; mean age 73.8 years) who underwent spinal fixation surgery for OVC with neurological deficits between 2005 and 2014 were enrolled. Data on patient demographics were collected, including age, sex, body mass index, smoking, steroid use, medical comorbidities, and surgical procedures. All postoperative complications that occurred within 6 weeks were recorded. Patients were classified into two groups, namely, complication group and no complication group, and risk factors for postoperative complications were investigated by univariate and multivariate analyses. Results: Postoperative complications occurred in 57 patients (14.1%), and the most common complication was delirium (5.7%). In the univariate analysis, the complication group was found to be older (p = 0.039) and predominantly male (p = 0.049), with higher occurrence rate of liver disease (p = 0.001) and Parkinson's disease (p = 0.039) compared with the no-complication group. In the multivariate analysis, the significant independent risk factors were age (p = 0.021; odds ratio [OR] 1.051, 95% confidence interval [CI] 1.007–1.097), liver disease (p < 0.001; OR 8.993, 95% CI 2.882–28.065), and Parkinson's disease (p = 0.009; OR 3.636, 95% CI 1.378–9.599). Conclusions: Complications after spinal fixation surgery for OVC with neurological deficits occurred in 14.1%. Age, liver disease, and Parkinson's disease were demonstrated to be independent risk factors for postoperative complications.

AB - Background: There have been few reports on the incidence and risk factors of the complications after spinal fixation surgery for osteoporotic vertebral collapse (OVC) with neurological deficits. This study aimed to identify the incidence and risk factors of the complications after OVC surgery. Methods: In this retrospective multicenter study, a total of 403 patients (314 women and 89 men; mean age 73.8 years) who underwent spinal fixation surgery for OVC with neurological deficits between 2005 and 2014 were enrolled. Data on patient demographics were collected, including age, sex, body mass index, smoking, steroid use, medical comorbidities, and surgical procedures. All postoperative complications that occurred within 6 weeks were recorded. Patients were classified into two groups, namely, complication group and no complication group, and risk factors for postoperative complications were investigated by univariate and multivariate analyses. Results: Postoperative complications occurred in 57 patients (14.1%), and the most common complication was delirium (5.7%). In the univariate analysis, the complication group was found to be older (p = 0.039) and predominantly male (p = 0.049), with higher occurrence rate of liver disease (p = 0.001) and Parkinson's disease (p = 0.039) compared with the no-complication group. In the multivariate analysis, the significant independent risk factors were age (p = 0.021; odds ratio [OR] 1.051, 95% confidence interval [CI] 1.007–1.097), liver disease (p < 0.001; OR 8.993, 95% CI 2.882–28.065), and Parkinson's disease (p = 0.009; OR 3.636, 95% CI 1.378–9.599). Conclusions: Complications after spinal fixation surgery for OVC with neurological deficits occurred in 14.1%. Age, liver disease, and Parkinson's disease were demonstrated to be independent risk factors for postoperative complications.

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U2 - 10.1016/j.jos.2019.08.015

DO - 10.1016/j.jos.2019.08.015

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SP - 985

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JO - Journal of Orthopaedic Science

JF - Journal of Orthopaedic Science

SN - 0949-2658

IS - 6

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