Abstract
Asymmetric cell division is a fundamental process that produces cellular diversity during development. We have identified two mutants in C. elegans (psa-1 and psa-4) in which the asymmetry of T cell division is disrupted. psa-1 and psa-4 encode homologs of yeast SW13 and SW12/SNF2, respectively, which are components of the SWI/SNF complex. We show by RNA interference assay that homologs of other components of SWI/SNF are also involved in T cell division. psa-1 and psa-4 are likely to be required in the T cell during mitosis to cause asymmetric cell division. Because the SWI/SNF complex is required for asymmetric division in S. cerevisiae, these results demonstrate that at least some aspects of the mechanism of asymmetric cell division are conserved between yeast and a multicellular organism.
| Original language | English |
|---|---|
| Pages (from-to) | 617-624 |
| Number of pages | 8 |
| Journal | Molecular Cell |
| Volume | 6 |
| Issue number | 3 |
| Publication status | Published - 2000 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Molecular Biology
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Components of the SWI/SNF complex are required for asymmetric cell division in C. elegans. / Sawa, Hitoshi; Kouike, Hiroko; Okano, Hideyuki.
In: Molecular Cell, Vol. 6, No. 3, 2000, p. 617-624.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Components of the SWI/SNF complex are required for asymmetric cell division in C. elegans
AU - Sawa, Hitoshi
AU - Kouike, Hiroko
AU - Okano, Hideyuki
PY - 2000
Y1 - 2000
N2 - Asymmetric cell division is a fundamental process that produces cellular diversity during development. We have identified two mutants in C. elegans (psa-1 and psa-4) in which the asymmetry of T cell division is disrupted. psa-1 and psa-4 encode homologs of yeast SW13 and SW12/SNF2, respectively, which are components of the SWI/SNF complex. We show by RNA interference assay that homologs of other components of SWI/SNF are also involved in T cell division. psa-1 and psa-4 are likely to be required in the T cell during mitosis to cause asymmetric cell division. Because the SWI/SNF complex is required for asymmetric division in S. cerevisiae, these results demonstrate that at least some aspects of the mechanism of asymmetric cell division are conserved between yeast and a multicellular organism.
AB - Asymmetric cell division is a fundamental process that produces cellular diversity during development. We have identified two mutants in C. elegans (psa-1 and psa-4) in which the asymmetry of T cell division is disrupted. psa-1 and psa-4 encode homologs of yeast SW13 and SW12/SNF2, respectively, which are components of the SWI/SNF complex. We show by RNA interference assay that homologs of other components of SWI/SNF are also involved in T cell division. psa-1 and psa-4 are likely to be required in the T cell during mitosis to cause asymmetric cell division. Because the SWI/SNF complex is required for asymmetric division in S. cerevisiae, these results demonstrate that at least some aspects of the mechanism of asymmetric cell division are conserved between yeast and a multicellular organism.
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UR - http://www.scopus.com/inward/citedby.url?scp=0033636901&partnerID=8YFLogxK
M3 - Article
C2 - 11030341
AN - SCOPUS:0033636901
VL - 6
SP - 617
EP - 624
JO - Molecular Cell
JF - Molecular Cell
SN - 1097-2765
IS - 3
ER -