Components of the SWI/SNF complex are required for asymmetric cell division in C. elegans

Hitoshi Sawa, Hiroko Kouike, Hideyuki Okano

Research output: Contribution to journalArticle

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Abstract

Asymmetric cell division is a fundamental process that produces cellular diversity during development. We have identified two mutants in C. elegans (psa-1 and psa-4) in which the asymmetry of T cell division is disrupted. psa-1 and psa-4 encode homologs of yeast SW13 and SW12/SNF2, respectively, which are components of the SWI/SNF complex. We show by RNA interference assay that homologs of other components of SWI/SNF are also involved in T cell division. psa-1 and psa-4 are likely to be required in the T cell during mitosis to cause asymmetric cell division. Because the SWI/SNF complex is required for asymmetric division in S. cerevisiae, these results demonstrate that at least some aspects of the mechanism of asymmetric cell division are conserved between yeast and a multicellular organism.

Original languageEnglish
Pages (from-to)617-624
Number of pages8
JournalMolecular Cell
Volume6
Issue number3
Publication statusPublished - 2000
Externally publishedYes

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Asymmetric Cell Division
T-Lymphocytes
Cell Division
Yeasts
RNA Interference
Mitosis
Saccharomyces cerevisiae

ASJC Scopus subject areas

  • Molecular Biology

Cite this

Components of the SWI/SNF complex are required for asymmetric cell division in C. elegans. / Sawa, Hitoshi; Kouike, Hiroko; Okano, Hideyuki.

In: Molecular Cell, Vol. 6, No. 3, 2000, p. 617-624.

Research output: Contribution to journalArticle

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