Components of the SWI/SNF complex are required for asymmetric cell division in C. elegans

Hitoshi Sawa; Hiroko Kouike; Hideyuki Okano

doi:10.1016/S1097-2765(00)00060-5

Components of the SWI/SNF complex are required for asymmetric cell division in C. elegans

Hitoshi Sawa, Hiroko Kouike, Hideyuki Okano

Research output: Contribution to journal › Article › peer-review

73 Citations (Scopus)

Abstract

Asymmetric cell division is a fundamental process that produces cellular diversity during development. We have identified two mutants in C. elegans (psa-1 and psa-4) in which the asymmetry of T cell division is disrupted. psa-1 and psa-4 encode homologs of yeast SW13 and SW12/SNF2, respectively, which are components of the SWI/SNF complex. We show by RNA interference assay that homologs of other components of SWI/SNF are also involved in T cell division. psa-1 and psa-4 are likely to be required in the T cell during mitosis to cause asymmetric cell division. Because the SWI/SNF complex is required for asymmetric division in S. cerevisiae, these results demonstrate that at least some aspects of the mechanism of asymmetric cell division are conserved between yeast and a multicellular organism.

Original language	English
Pages (from-to)	617-624
Number of pages	8
Journal	Molecular Cell
Volume	6
Issue number	3
DOIs	https://doi.org/10.1016/S1097-2765(00)00060-5
Publication status	Published - 2000
Externally published	Yes

ASJC Scopus subject areas

Molecular Biology
Cell Biology

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title = "Components of the SWI/SNF complex are required for asymmetric cell division in C. elegans",

abstract = "Asymmetric cell division is a fundamental process that produces cellular diversity during development. We have identified two mutants in C. elegans (psa-1 and psa-4) in which the asymmetry of T cell division is disrupted. psa-1 and psa-4 encode homologs of yeast SW13 and SW12/SNF2, respectively, which are components of the SWI/SNF complex. We show by RNA interference assay that homologs of other components of SWI/SNF are also involved in T cell division. psa-1 and psa-4 are likely to be required in the T cell during mitosis to cause asymmetric cell division. Because the SWI/SNF complex is required for asymmetric division in S. cerevisiae, these results demonstrate that at least some aspects of the mechanism of asymmetric cell division are conserved between yeast and a multicellular organism.",

author = "Hitoshi Sawa and Hiroko Kouike and Hideyuki Okano",

note = "Funding Information: Many of the strains used to map psa-1 and psa-4 were provided by the Caenorhabditis Genetic Center, which is funded by the NIH's National Center for Research Resources. We thank Craig Mello for comments on the manuscript, Yuji Kohara for providing cDNAs, and A. Yoda and R. Shimamura for technical assistance. This work was supported by grants from PRESTO (H. S.) and CREST of the Japan Science and Technology Corporation, the Japanese Ministry of Education, Science and Culture, and Human Science Frontier Program (H. O.). ",

year = "2000",

doi = "10.1016/S1097-2765(00)00060-5",

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T1 - Components of the SWI/SNF complex are required for asymmetric cell division in C. elegans

AU - Sawa, Hitoshi

AU - Kouike, Hiroko

AU - Okano, Hideyuki

N1 - Funding Information: Many of the strains used to map psa-1 and psa-4 were provided by the Caenorhabditis Genetic Center, which is funded by the NIH's National Center for Research Resources. We thank Craig Mello for comments on the manuscript, Yuji Kohara for providing cDNAs, and A. Yoda and R. Shimamura for technical assistance. This work was supported by grants from PRESTO (H. S.) and CREST of the Japan Science and Technology Corporation, the Japanese Ministry of Education, Science and Culture, and Human Science Frontier Program (H. O.).

PY - 2000

Y1 - 2000

N2 - Asymmetric cell division is a fundamental process that produces cellular diversity during development. We have identified two mutants in C. elegans (psa-1 and psa-4) in which the asymmetry of T cell division is disrupted. psa-1 and psa-4 encode homologs of yeast SW13 and SW12/SNF2, respectively, which are components of the SWI/SNF complex. We show by RNA interference assay that homologs of other components of SWI/SNF are also involved in T cell division. psa-1 and psa-4 are likely to be required in the T cell during mitosis to cause asymmetric cell division. Because the SWI/SNF complex is required for asymmetric division in S. cerevisiae, these results demonstrate that at least some aspects of the mechanism of asymmetric cell division are conserved between yeast and a multicellular organism.

AB - Asymmetric cell division is a fundamental process that produces cellular diversity during development. We have identified two mutants in C. elegans (psa-1 and psa-4) in which the asymmetry of T cell division is disrupted. psa-1 and psa-4 encode homologs of yeast SW13 and SW12/SNF2, respectively, which are components of the SWI/SNF complex. We show by RNA interference assay that homologs of other components of SWI/SNF are also involved in T cell division. psa-1 and psa-4 are likely to be required in the T cell during mitosis to cause asymmetric cell division. Because the SWI/SNF complex is required for asymmetric division in S. cerevisiae, these results demonstrate that at least some aspects of the mechanism of asymmetric cell division are conserved between yeast and a multicellular organism.

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Components of the SWI/SNF complex are required for asymmetric cell division in C. elegans

Abstract

ASJC Scopus subject areas

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