Comprehensive risk score of the E-PASS as a prognostic indicator for patients after elective and emergency curative colorectal cancer surgery: A multicenter retrospective study

Yujin Kato, Kohei Shigeta, Yuki Tajima, Hiroto Kikuchi, Akira Hirata, Jumpei Nakadai, Kiyoaki Sugiura, Yuki Seo, Takayuki Kondo, Jun Okui, Shimpei Matsui, Ryo Seishima, Koji Okabayashi, Yuko Kitagawa

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: To evaluate the prognostic value of the comprehensive risk score (CRS) of the Estimation of Physiologic Ability and Surgical Stress for managing patients with colorectal cancer (CRC) who underwent elective and emergency colorectal cancer surgery with curative intent. Summary background data: CRS, which is calculated based on both clinical and surgical factors, is a good predictor of postoperative complications and mortality. However, the impact of CRS in CRC prognosis remains unclear. Methods: Patients with CRC who underwent curative resection between 2010 and 2019 were retrospectively enrolled in this study. The cohort was divided into the low and high CRS groups. The prognostic value of CRS was evaluated via Cox regression and Kaplan–Meier analyses. The CRS cutoff value was obtained using the Youden index applied to OS curves and have not been validated by any validation cohorts. Results: In total, 2407 patients, including 1359 and 1048 patients with low and high CRS, respectively, were enrolled in this study. Multivariate analysis revealed that a CRS was an independent prognostic factor of overall and recurrence-free survival regardless of disease stage. Furthermore, adjuvant chemotherapy was beneficial for the survival of patients with stage III CRC in both high and low CRS groups; however, the survival benefit was limited in elderly high CRS patients. Conclusions: CRS was a strong prognostic factor for CRC regardless of disease stage and might be considered as a biomarker for selecting elderly patients who are eligible for adjuvant chemotherapy.

Original languageEnglish
Article number106631
JournalInternational Journal of Surgery
Volume101
DOIs
Publication statusPublished - 2022 May

Keywords

  • Adjuvant chemotherapy
  • Colorectal cancer
  • Comprehensive risk score
  • Estimation of physiologic ability and surgical stress
  • Prognostic outcome

ASJC Scopus subject areas

  • Surgery

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