Computational analysis of microRNA-mediated antiviral defense in humans

Yuka Watanabe; Atsuko Kishi; Nozomu Yachie; Akio Kanai; Masaru Tomita

doi:10.1016/j.febslet.2007.08.049

Computational analysis of microRNA-mediated antiviral defense in humans

Yuka Watanabe, Atsuko Kishi, Nozomu Yachie, Akio Kanai, Masaru Tomita

Faculty of Environment and Information Studies

Research output: Contribution to journal › Article › peer-review

35 Citations (Scopus)

Abstract

Recent studies have proposed the interesting perspective that viral gene expression is downregulated by host microRNAs (miRNAs), small non-coding RNAs well known as post-transcriptional gene regulators. We computationally predicted human miRNA target sites within 228 human-infecting and 348 invertebrate-infecting virus genomes, and we observed that human-infecting viruses were more likely than invertebrate-infecting ones to be targeted by human miRNAs. We listed 62 possible human miRNA-targeted viruses from 6 families, most of which consisted of single-stranded RNA viruses. These results suggest that miRNAs extensively mediate antiviral defenses in humans.

Original language	English
Pages (from-to)	4603-4610
Number of pages	8
Journal	FEBS Letters
Volume	581
Issue number	24
DOIs	https://doi.org/10.1016/j.febslet.2007.08.049
Publication status	Published - 2007 Oct 2

Keywords

Bioinformatics
Homo sapiens
MicroRNA
TargetScan
ssRNA-positive strand virus

ASJC Scopus subject areas

Biophysics
Structural Biology
Biochemistry
Molecular Biology
Genetics
Cell Biology

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