Abstract
Recent studies have proposed the interesting perspective that viral gene expression is downregulated by host microRNAs (miRNAs), small non-coding RNAs well known as post-transcriptional gene regulators. We computationally predicted human miRNA target sites within 228 human-infecting and 348 invertebrate-infecting virus genomes, and we observed that human-infecting viruses were more likely than invertebrate-infecting ones to be targeted by human miRNAs. We listed 62 possible human miRNA-targeted viruses from 6 families, most of which consisted of single-stranded RNA viruses. These results suggest that miRNAs extensively mediate antiviral defenses in humans.
| Original language | English |
|---|---|
| Pages (from-to) | 4603-4610 |
| Number of pages | 8 |
| Journal | FEBS Letters |
| Volume | 581 |
| Issue number | 24 |
| DOIs | |
| Publication status | Published - 2007 Oct 2 |
Keywords
- Bioinformatics
- Homo sapiens
- MicroRNA
- TargetScan
- ssRNA-positive strand virus
ASJC Scopus subject areas
- Biophysics
- Structural Biology
- Biochemistry
- Molecular Biology
- Genetics
- Cell Biology
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Cite this
Watanabe, Y., Kishi, A., Yachie, N., Kanai, A., & Tomita, M. (2007). Computational analysis of microRNA-mediated antiviral defense in humans. FEBS Letters, 581(24), 4603-4610. https://doi.org/10.1016/j.febslet.2007.08.049