Abstract
Recent studies have proposed the interesting perspective that viral gene expression is downregulated by host microRNAs (miRNAs), small non-coding RNAs well known as post-transcriptional gene regulators. We computationally predicted human miRNA target sites within 228 human-infecting and 348 invertebrate-infecting virus genomes, and we observed that human-infecting viruses were more likely than invertebrate-infecting ones to be targeted by human miRNAs. We listed 62 possible human miRNA-targeted viruses from 6 families, most of which consisted of single-stranded RNA viruses. These results suggest that miRNAs extensively mediate antiviral defenses in humans.
| Original language | English |
|---|---|
| Pages (from-to) | 4603-4610 |
| Number of pages | 8 |
| Journal | FEBS Letters |
| Volume | 581 |
| Issue number | 24 |
| DOIs | |
| Publication status | Published - 2007 Oct 2 |
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Keywords
- Bioinformatics
- Homo sapiens
- MicroRNA
- ssRNA-positive strand virus
- TargetScan
ASJC Scopus subject areas
- Biochemistry
- Biophysics
- Molecular Biology
Cite this
Computational analysis of microRNA-mediated antiviral defense in humans. / Watanabe, Yuka; Kishi, Atsuko; Yachie, Nozomu; Kanai, Akio; Tomita, Masaru.
In: FEBS Letters, Vol. 581, No. 24, 02.10.2007, p. 4603-4610.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Computational analysis of microRNA-mediated antiviral defense in humans
AU - Watanabe, Yuka
AU - Kishi, Atsuko
AU - Yachie, Nozomu
AU - Kanai, Akio
AU - Tomita, Masaru
PY - 2007/10/2
Y1 - 2007/10/2
N2 - Recent studies have proposed the interesting perspective that viral gene expression is downregulated by host microRNAs (miRNAs), small non-coding RNAs well known as post-transcriptional gene regulators. We computationally predicted human miRNA target sites within 228 human-infecting and 348 invertebrate-infecting virus genomes, and we observed that human-infecting viruses were more likely than invertebrate-infecting ones to be targeted by human miRNAs. We listed 62 possible human miRNA-targeted viruses from 6 families, most of which consisted of single-stranded RNA viruses. These results suggest that miRNAs extensively mediate antiviral defenses in humans.
AB - Recent studies have proposed the interesting perspective that viral gene expression is downregulated by host microRNAs (miRNAs), small non-coding RNAs well known as post-transcriptional gene regulators. We computationally predicted human miRNA target sites within 228 human-infecting and 348 invertebrate-infecting virus genomes, and we observed that human-infecting viruses were more likely than invertebrate-infecting ones to be targeted by human miRNAs. We listed 62 possible human miRNA-targeted viruses from 6 families, most of which consisted of single-stranded RNA viruses. These results suggest that miRNAs extensively mediate antiviral defenses in humans.
KW - Bioinformatics
KW - Homo sapiens
KW - MicroRNA
KW - ssRNA-positive strand virus
KW - TargetScan
UR - http://www.scopus.com/inward/record.url?scp=34548683716&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34548683716&partnerID=8YFLogxK
U2 - 10.1016/j.febslet.2007.08.049
DO - 10.1016/j.febslet.2007.08.049
M3 - Article
C2 - 17825824
AN - SCOPUS:34548683716
VL - 581
SP - 4603
EP - 4610
JO - FEBS Letters
JF - FEBS Letters
SN - 0014-5793
IS - 24
ER -