Computational analysis of microRNA-mediated antiviral defense in humans

Yuka Watanabe, Atsuko Kishi, Nozomu Yachie, Akio Kanai, Masaru Tomita

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Recent studies have proposed the interesting perspective that viral gene expression is downregulated by host microRNAs (miRNAs), small non-coding RNAs well known as post-transcriptional gene regulators. We computationally predicted human miRNA target sites within 228 human-infecting and 348 invertebrate-infecting virus genomes, and we observed that human-infecting viruses were more likely than invertebrate-infecting ones to be targeted by human miRNAs. We listed 62 possible human miRNA-targeted viruses from 6 families, most of which consisted of single-stranded RNA viruses. These results suggest that miRNAs extensively mediate antiviral defenses in humans.

Original languageEnglish
Pages (from-to)4603-4610
Number of pages8
JournalFEBS Letters
Volume581
Issue number24
DOIs
Publication statusPublished - 2007 Oct 2

Fingerprint

MicroRNAs
Antiviral Agents
Viruses
Invertebrates
Genes
Small Untranslated RNA
Viral Genes
RNA Viruses
Human Genome
Regulator Genes
Gene expression
Down-Regulation
RNA
Gene Expression

Keywords

  • Bioinformatics
  • Homo sapiens
  • MicroRNA
  • ssRNA-positive strand virus
  • TargetScan

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Computational analysis of microRNA-mediated antiviral defense in humans. / Watanabe, Yuka; Kishi, Atsuko; Yachie, Nozomu; Kanai, Akio; Tomita, Masaru.

In: FEBS Letters, Vol. 581, No. 24, 02.10.2007, p. 4603-4610.

Research output: Contribution to journalArticle

Watanabe, Yuka ; Kishi, Atsuko ; Yachie, Nozomu ; Kanai, Akio ; Tomita, Masaru. / Computational analysis of microRNA-mediated antiviral defense in humans. In: FEBS Letters. 2007 ; Vol. 581, No. 24. pp. 4603-4610.
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