Abstract
In type 2 diabetes mellitus, glucose homeostasis is tightly maintained through insulin secretion and insulin sensitivity. Therefore, finding an accurate method to assess insulin secretion and sensitivity using clinically available data would enhance the quality of diabetic medical care. In an effort to find such a method, we developed a computational approach to derive indices of these factors using a 2-h oral glucose tolerance test (OGTT). To evaluate our method, clinical data from subjects who received an OGTT and a glucose clamp test were examined. Our insulin secretion index was significantly correlated with an analogous index obtained from a hyperglycemic clamp test (r = 0.90, n = 46, p < 0.001). Our insulin sensitivity index sensitivity was also significantly correlated with an analogous index obtained from a hyperinsulinemic-euglycemic clamp test (r = 0.56, n = 79, p < 0.001). These results suggest that our method can potentially provide an accurate and convenient tool toward improving the management of diabetes in clinical practice by assessing insulin secretion and insulin sensitivity.
| Original language | English |
|---|---|
| Pages (from-to) | 321-330 |
| Number of pages | 10 |
| Journal | Journal of Physiological Sciences |
| Volume | 61 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 2011 Jul |
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Keywords
- Clinical use
- Insulin secretion
- Insulin sensitivity
- Mathematical model
- OGTT
- Type 2 diabetes
ASJC Scopus subject areas
- Physiology
Cite this
Computational assessment of insulin secretion and insulin sensitivity from 2-h oral glucose tolerance tests for clinical use for type 2 diabetes. / Seike, Masayoshi; Saitou, Takeo; Kouchi, Yasuhiro; Ohara, Takeshi; Matsuhisa, Munehide; Sakaguchi, Kazuhiko; Tomita, Koji; Kosugi, Keisuke; Kashiwagi, Atsunori; Kasuga, Masato; Tomita, Masaru; Naito, Yasuhiro; Nakajima, Hiromu.
In: Journal of Physiological Sciences, Vol. 61, No. 4, 07.2011, p. 321-330.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Computational assessment of insulin secretion and insulin sensitivity from 2-h oral glucose tolerance tests for clinical use for type 2 diabetes
AU - Seike, Masayoshi
AU - Saitou, Takeo
AU - Kouchi, Yasuhiro
AU - Ohara, Takeshi
AU - Matsuhisa, Munehide
AU - Sakaguchi, Kazuhiko
AU - Tomita, Koji
AU - Kosugi, Keisuke
AU - Kashiwagi, Atsunori
AU - Kasuga, Masato
AU - Tomita, Masaru
AU - Naito, Yasuhiro
AU - Nakajima, Hiromu
PY - 2011/7
Y1 - 2011/7
N2 - In type 2 diabetes mellitus, glucose homeostasis is tightly maintained through insulin secretion and insulin sensitivity. Therefore, finding an accurate method to assess insulin secretion and sensitivity using clinically available data would enhance the quality of diabetic medical care. In an effort to find such a method, we developed a computational approach to derive indices of these factors using a 2-h oral glucose tolerance test (OGTT). To evaluate our method, clinical data from subjects who received an OGTT and a glucose clamp test were examined. Our insulin secretion index was significantly correlated with an analogous index obtained from a hyperglycemic clamp test (r = 0.90, n = 46, p < 0.001). Our insulin sensitivity index sensitivity was also significantly correlated with an analogous index obtained from a hyperinsulinemic-euglycemic clamp test (r = 0.56, n = 79, p < 0.001). These results suggest that our method can potentially provide an accurate and convenient tool toward improving the management of diabetes in clinical practice by assessing insulin secretion and insulin sensitivity.
AB - In type 2 diabetes mellitus, glucose homeostasis is tightly maintained through insulin secretion and insulin sensitivity. Therefore, finding an accurate method to assess insulin secretion and sensitivity using clinically available data would enhance the quality of diabetic medical care. In an effort to find such a method, we developed a computational approach to derive indices of these factors using a 2-h oral glucose tolerance test (OGTT). To evaluate our method, clinical data from subjects who received an OGTT and a glucose clamp test were examined. Our insulin secretion index was significantly correlated with an analogous index obtained from a hyperglycemic clamp test (r = 0.90, n = 46, p < 0.001). Our insulin sensitivity index sensitivity was also significantly correlated with an analogous index obtained from a hyperinsulinemic-euglycemic clamp test (r = 0.56, n = 79, p < 0.001). These results suggest that our method can potentially provide an accurate and convenient tool toward improving the management of diabetes in clinical practice by assessing insulin secretion and insulin sensitivity.
KW - Clinical use
KW - Insulin secretion
KW - Insulin sensitivity
KW - Mathematical model
KW - OGTT
KW - Type 2 diabetes
UR - http://www.scopus.com/inward/record.url?scp=79960834026&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79960834026&partnerID=8YFLogxK
U2 - 10.1007/s12576-011-0153-z
DO - 10.1007/s12576-011-0153-z
M3 - Article
C2 - 21594678
AN - SCOPUS:79960834026
VL - 61
SP - 321
EP - 330
JO - Journal of Physiological Sciences
JF - Journal of Physiological Sciences
SN - 1880-6546
IS - 4
ER -