Computational assessment of insulin secretion and insulin sensitivity from 2-h oral glucose tolerance tests for clinical use for type 2 diabetes

Masayoshi Seike, Takeo Saitou, Yasuhiro Kouchi, Takeshi Ohara, Munehide Matsuhisa, Kazuhiko Sakaguchi, Koji Tomita, Keisuke Kosugi, Atsunori Kashiwagi, Masato Kasuga, Masaru Tomita, Yasuhiro Naito, Hiromu Nakajima

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3 Citations (Scopus)

Abstract

In type 2 diabetes mellitus, glucose homeostasis is tightly maintained through insulin secretion and insulin sensitivity. Therefore, finding an accurate method to assess insulin secretion and sensitivity using clinically available data would enhance the quality of diabetic medical care. In an effort to find such a method, we developed a computational approach to derive indices of these factors using a 2-h oral glucose tolerance test (OGTT). To evaluate our method, clinical data from subjects who received an OGTT and a glucose clamp test were examined. Our insulin secretion index was significantly correlated with an analogous index obtained from a hyperglycemic clamp test (r = 0.90, n = 46, p < 0.001). Our insulin sensitivity index sensitivity was also significantly correlated with an analogous index obtained from a hyperinsulinemic-euglycemic clamp test (r = 0.56, n = 79, p < 0.001). These results suggest that our method can potentially provide an accurate and convenient tool toward improving the management of diabetes in clinical practice by assessing insulin secretion and insulin sensitivity.

Original languageEnglish
Pages (from-to)321-330
Number of pages10
JournalJournal of Physiological Sciences
Volume61
Issue number4
DOIs
Publication statusPublished - 2011 Jul 1

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Keywords

  • Clinical use
  • Insulin secretion
  • Insulin sensitivity
  • Mathematical model
  • OGTT
  • Type 2 diabetes

ASJC Scopus subject areas

  • Physiology

Cite this

Seike, M., Saitou, T., Kouchi, Y., Ohara, T., Matsuhisa, M., Sakaguchi, K., Tomita, K., Kosugi, K., Kashiwagi, A., Kasuga, M., Tomita, M., Naito, Y., & Nakajima, H. (2011). Computational assessment of insulin secretion and insulin sensitivity from 2-h oral glucose tolerance tests for clinical use for type 2 diabetes. Journal of Physiological Sciences, 61(4), 321-330. https://doi.org/10.1007/s12576-011-0153-z