@inbook{2e22a81ac0d541e7aa6182940a116b23,
title = "Computational Simulation of Tumor-Induced Angiogenesis",
abstract = "Cancer cells require higher oxygen levels and nutrition than normal cells. Cancer cells induce angiogenesis (the development of new blood vessels) from preexisting vessels. This biological process depends on the special, chemical, and physical properties of the microenvironment surrounding tumor tissues. The complexity of these properties hinders an understanding of their mechanisms. Various mathematical models have been developed to describe quantitative relationships related to angiogenesis. We developed a three-dimensional mathematical model that incorporates angiogenesis and tumor growth. We examined angiopoietin, which regulates the spouting and branching events in angiogenesis. The simulation successfully reproduced the transient decrease in new vessels during vascular network formation. This chapter describes the protocol used to perform the simulations.",
keywords = "Angiogenesis, Cancer, Simulation, Systems biology, Tumor",
author = "Masahiro Sugimoto",
note = "Funding Information: This research was funded by grants from JSPS KAKENHI (grant numbers 20B205). Publisher Copyright: {\textcopyright} 2023, The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.",
year = "2023",
doi = "10.1007/978-1-0716-2617-7_14",
language = "English",
series = "Methods in Molecular Biology",
publisher = "Humana Press Inc.",
pages = "275--283",
booktitle = "Methods in Molecular Biology",
}
