TY - JOUR
T1 - Computer-aided prediction of long-term prognosis of patients with ulcerative colitis after cytoapheresis therapy
AU - Takayama, Tetsuro
AU - Okamoto, Susumu
AU - Hisamatsu, Tadakazu
AU - Naganuma, Makoto
AU - Matsuoka, Katsuyoshi
AU - Mizuno, Shinta
AU - Bessho, Rieko
AU - Hibi, Toshifumi
AU - Kanai, Takanori
N1 - Publisher Copyright:
© 2015 Takayama et al.
PY - 2015/6/25
Y1 - 2015/6/25
N2 - Cytoapheresis (CAP) therapy is widely used in ulcerative colitis (UC) patients with moderate to severe activity in Japan. The aim of this study is to predict the need of operation after CAP therapy of UC patients on an individual level using an artificial neural network system (ANN). Ninety UC patients with moderate to severe activity were treated with CAP. Data on the patients' demographics, medication, clinical activity index (CAI) and efficacy of CAP were collected. Clinical data were divided into training data group and validation data group and analyzed using ANN to predict individual outcomes. The sensitivity and specificity of predictive expression by ANN were 0.96 and 0.97, respectively. Events of admission, operation, and use of immunomodulator, and efficacy of CAP were significantly correlated to the outcome. Requirement of operation after CAP therapy was successfully predicted by using ANN. This newly established ANN strategy would be used as powerful support of physicians in the clinical practice.
AB - Cytoapheresis (CAP) therapy is widely used in ulcerative colitis (UC) patients with moderate to severe activity in Japan. The aim of this study is to predict the need of operation after CAP therapy of UC patients on an individual level using an artificial neural network system (ANN). Ninety UC patients with moderate to severe activity were treated with CAP. Data on the patients' demographics, medication, clinical activity index (CAI) and efficacy of CAP were collected. Clinical data were divided into training data group and validation data group and analyzed using ANN to predict individual outcomes. The sensitivity and specificity of predictive expression by ANN were 0.96 and 0.97, respectively. Events of admission, operation, and use of immunomodulator, and efficacy of CAP were significantly correlated to the outcome. Requirement of operation after CAP therapy was successfully predicted by using ANN. This newly established ANN strategy would be used as powerful support of physicians in the clinical practice.
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U2 - 10.1371/journal.pone.0131197
DO - 10.1371/journal.pone.0131197
M3 - Article
C2 - 26111148
AN - SCOPUS:84938357712
SN - 1932-6203
VL - 10
JO - PLoS One
JF - PLoS One
IS - 6
M1 - e0131197
ER -