Conception and pregnancy outcome in women with inflammatory bowel disease: A multicentre study from Japan

Makoto Naganuma, Reiko Kunisaki, Naoki Yoshimura, Masakazu Nagahori, Hisae Yamamoto, Hideaki Kimura, Minako Sako, Takaaki Kawaguchi, Masakazu Takazoe, Shojiro Yamamoto, Toshiyuki Matsui, Toshifumi Hibi, Mamoru Watanabe

Research output: Contribution to journalArticle

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Abstract

Background: Neither conceptions and pregnancy outcomes nor the safety of medications for childbearing inflammatory bowel disease (IBD) patients has been investigated in Asia. The aim of this study is to analyse conception and pregnancy outcomes of Japanese female IBD patients. Methods: We conducted a retrospective cohort study of pregnant IBD patients at 6 institutions. The incidences of abortion, Caesarean delivery, low birth weight (LBW) (< 2500. g), and congenital malformation were analysed in these patients. Risk factors associated with adverse outcomes in IBD patients were also assessed. Results: A total of 325 patients experienced 534 conceptions. Among these, 303 conceptions (57%) were observed during/after disease onset. Although conceptions and pregnancy outcomes after disease onset were comparable to the observed levels prior to disease onset in UC patients, the incidences of spontaneous abortion (OR 5.3; 95%CI 1.1-25.0) and Caesarean delivery (OR 4.8; 95%CI 1.5-15.0) were significantly higher in Crohn's disease (CD) patients whose conceptions occurred after disease onset compared to CD patients whose conceptions occurred before disease onset. The incidences of spontaneous abortion, LBW, and Caesarean delivery were higher in CD patients who had a history of surgery for perianal lesions than in those who did not have perianal lesions or who had ulcerative colitis (UC). In the IBD patients studied after disease onset, independent risk factors for spontaneous abortions included a history of previous treatment for sterility (OR 2.9; 95%CI 1.2-7.0). Independent risk factors for Caesarean operation (OR 4.1, 95% CI: 1.7-10.1) and LBW (OR 3.5, 95% CI: 1.3-9.1) included a history of bowel resection for the treatment of IBD. Congenital malformation was not associated with the factors of type of disease, smoking, and previous surgery. Conclusion: In Japanese UC patients, conception and pregnancy outcomes after disease onset were comparable to the outcomes observed prior to disease onset, whereas CD appeared to be associated with adverse outcomes. Caesarean operation and LBW were more frequently observed in CD patients who had a history of surgery for perianal lesions and bowel resection.

Original languageEnglish
Pages (from-to)317-323
Number of pages7
JournalJournal of Crohn's and Colitis
Volume5
Issue number4
DOIs
Publication statusPublished - 2011 Sep

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Pregnancy Outcome
Inflammatory Bowel Diseases
Multicenter Studies
Japan
Crohn Disease
Low Birth Weight Infant
Spontaneous Abortion
Ulcerative Colitis
Incidence
Infertility
Cohort Studies
Retrospective Studies
Smoking

Keywords

  • Inflammatory bowel disease
  • Perianal lesion
  • Pregnancy

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Conception and pregnancy outcome in women with inflammatory bowel disease : A multicentre study from Japan. / Naganuma, Makoto; Kunisaki, Reiko; Yoshimura, Naoki; Nagahori, Masakazu; Yamamoto, Hisae; Kimura, Hideaki; Sako, Minako; Kawaguchi, Takaaki; Takazoe, Masakazu; Yamamoto, Shojiro; Matsui, Toshiyuki; Hibi, Toshifumi; Watanabe, Mamoru.

In: Journal of Crohn's and Colitis, Vol. 5, No. 4, 09.2011, p. 317-323.

Research output: Contribution to journalArticle

Naganuma, M, Kunisaki, R, Yoshimura, N, Nagahori, M, Yamamoto, H, Kimura, H, Sako, M, Kawaguchi, T, Takazoe, M, Yamamoto, S, Matsui, T, Hibi, T & Watanabe, M 2011, 'Conception and pregnancy outcome in women with inflammatory bowel disease: A multicentre study from Japan', Journal of Crohn's and Colitis, vol. 5, no. 4, pp. 317-323. https://doi.org/10.1016/j.crohns.2011.02.003
Naganuma, Makoto ; Kunisaki, Reiko ; Yoshimura, Naoki ; Nagahori, Masakazu ; Yamamoto, Hisae ; Kimura, Hideaki ; Sako, Minako ; Kawaguchi, Takaaki ; Takazoe, Masakazu ; Yamamoto, Shojiro ; Matsui, Toshiyuki ; Hibi, Toshifumi ; Watanabe, Mamoru. / Conception and pregnancy outcome in women with inflammatory bowel disease : A multicentre study from Japan. In: Journal of Crohn's and Colitis. 2011 ; Vol. 5, No. 4. pp. 317-323.
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abstract = "Background: Neither conceptions and pregnancy outcomes nor the safety of medications for childbearing inflammatory bowel disease (IBD) patients has been investigated in Asia. The aim of this study is to analyse conception and pregnancy outcomes of Japanese female IBD patients. Methods: We conducted a retrospective cohort study of pregnant IBD patients at 6 institutions. The incidences of abortion, Caesarean delivery, low birth weight (LBW) (< 2500. g), and congenital malformation were analysed in these patients. Risk factors associated with adverse outcomes in IBD patients were also assessed. Results: A total of 325 patients experienced 534 conceptions. Among these, 303 conceptions (57{\%}) were observed during/after disease onset. Although conceptions and pregnancy outcomes after disease onset were comparable to the observed levels prior to disease onset in UC patients, the incidences of spontaneous abortion (OR 5.3; 95{\%}CI 1.1-25.0) and Caesarean delivery (OR 4.8; 95{\%}CI 1.5-15.0) were significantly higher in Crohn's disease (CD) patients whose conceptions occurred after disease onset compared to CD patients whose conceptions occurred before disease onset. The incidences of spontaneous abortion, LBW, and Caesarean delivery were higher in CD patients who had a history of surgery for perianal lesions than in those who did not have perianal lesions or who had ulcerative colitis (UC). In the IBD patients studied after disease onset, independent risk factors for spontaneous abortions included a history of previous treatment for sterility (OR 2.9; 95{\%}CI 1.2-7.0). Independent risk factors for Caesarean operation (OR 4.1, 95{\%} CI: 1.7-10.1) and LBW (OR 3.5, 95{\%} CI: 1.3-9.1) included a history of bowel resection for the treatment of IBD. Congenital malformation was not associated with the factors of type of disease, smoking, and previous surgery. Conclusion: In Japanese UC patients, conception and pregnancy outcomes after disease onset were comparable to the outcomes observed prior to disease onset, whereas CD appeared to be associated with adverse outcomes. Caesarean operation and LBW were more frequently observed in CD patients who had a history of surgery for perianal lesions and bowel resection.",
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AU - Yamamoto, Hisae

AU - Kimura, Hideaki

AU - Sako, Minako

AU - Kawaguchi, Takaaki

AU - Takazoe, Masakazu

AU - Yamamoto, Shojiro

AU - Matsui, Toshiyuki

AU - Hibi, Toshifumi

AU - Watanabe, Mamoru

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N2 - Background: Neither conceptions and pregnancy outcomes nor the safety of medications for childbearing inflammatory bowel disease (IBD) patients has been investigated in Asia. The aim of this study is to analyse conception and pregnancy outcomes of Japanese female IBD patients. Methods: We conducted a retrospective cohort study of pregnant IBD patients at 6 institutions. The incidences of abortion, Caesarean delivery, low birth weight (LBW) (< 2500. g), and congenital malformation were analysed in these patients. Risk factors associated with adverse outcomes in IBD patients were also assessed. Results: A total of 325 patients experienced 534 conceptions. Among these, 303 conceptions (57%) were observed during/after disease onset. Although conceptions and pregnancy outcomes after disease onset were comparable to the observed levels prior to disease onset in UC patients, the incidences of spontaneous abortion (OR 5.3; 95%CI 1.1-25.0) and Caesarean delivery (OR 4.8; 95%CI 1.5-15.0) were significantly higher in Crohn's disease (CD) patients whose conceptions occurred after disease onset compared to CD patients whose conceptions occurred before disease onset. The incidences of spontaneous abortion, LBW, and Caesarean delivery were higher in CD patients who had a history of surgery for perianal lesions than in those who did not have perianal lesions or who had ulcerative colitis (UC). In the IBD patients studied after disease onset, independent risk factors for spontaneous abortions included a history of previous treatment for sterility (OR 2.9; 95%CI 1.2-7.0). Independent risk factors for Caesarean operation (OR 4.1, 95% CI: 1.7-10.1) and LBW (OR 3.5, 95% CI: 1.3-9.1) included a history of bowel resection for the treatment of IBD. Congenital malformation was not associated with the factors of type of disease, smoking, and previous surgery. Conclusion: In Japanese UC patients, conception and pregnancy outcomes after disease onset were comparable to the outcomes observed prior to disease onset, whereas CD appeared to be associated with adverse outcomes. Caesarean operation and LBW were more frequently observed in CD patients who had a history of surgery for perianal lesions and bowel resection.

AB - Background: Neither conceptions and pregnancy outcomes nor the safety of medications for childbearing inflammatory bowel disease (IBD) patients has been investigated in Asia. The aim of this study is to analyse conception and pregnancy outcomes of Japanese female IBD patients. Methods: We conducted a retrospective cohort study of pregnant IBD patients at 6 institutions. The incidences of abortion, Caesarean delivery, low birth weight (LBW) (< 2500. g), and congenital malformation were analysed in these patients. Risk factors associated with adverse outcomes in IBD patients were also assessed. Results: A total of 325 patients experienced 534 conceptions. Among these, 303 conceptions (57%) were observed during/after disease onset. Although conceptions and pregnancy outcomes after disease onset were comparable to the observed levels prior to disease onset in UC patients, the incidences of spontaneous abortion (OR 5.3; 95%CI 1.1-25.0) and Caesarean delivery (OR 4.8; 95%CI 1.5-15.0) were significantly higher in Crohn's disease (CD) patients whose conceptions occurred after disease onset compared to CD patients whose conceptions occurred before disease onset. The incidences of spontaneous abortion, LBW, and Caesarean delivery were higher in CD patients who had a history of surgery for perianal lesions than in those who did not have perianal lesions or who had ulcerative colitis (UC). In the IBD patients studied after disease onset, independent risk factors for spontaneous abortions included a history of previous treatment for sterility (OR 2.9; 95%CI 1.2-7.0). Independent risk factors for Caesarean operation (OR 4.1, 95% CI: 1.7-10.1) and LBW (OR 3.5, 95% CI: 1.3-9.1) included a history of bowel resection for the treatment of IBD. Congenital malformation was not associated with the factors of type of disease, smoking, and previous surgery. Conclusion: In Japanese UC patients, conception and pregnancy outcomes after disease onset were comparable to the outcomes observed prior to disease onset, whereas CD appeared to be associated with adverse outcomes. Caesarean operation and LBW were more frequently observed in CD patients who had a history of surgery for perianal lesions and bowel resection.

KW - Inflammatory bowel disease

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