Conception outcomes and opinions about pregnancy for men with inflammatory bowel disease

Asaka Sato, Makoto Naganuma, Keiko Asakura, Yuji Nishiwaki, Tomoharu Yajima, Tadakazu Hisamatsu, Yasushi Iwao, Toru Takebayashi, Mamoru Watanabe, Toshifumi Hibi

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Background and aims: Patients with inflammatory bowel disease (IBD) who want to have children are anxious to receive medical treatment. The consensus regarding pregnancy has not been surveyed for male IBD patients. The present study was investigated opinions among male IBD patients about pregnancy, conception and neonatal outcomes for partners. Methods: Subjects comprised 364 of 386 patients enrolled (94.3%). Subjects received a questionnaire regarding their opinions and thoughts about pregnancy. The course of partner's conceptions and presence of neonatal malformations was also surveyed. Results: The rate of live births for partners of male IBD patients was 91.6% (219/239). Most patients with CD (29/33; 88%) had their children after surgery had been performed. The rate of expressing hopes to have a child tended to be higher for patients with UC (93/128; 73%) than for patients with CD (61/97; 63%; p = 0.21). Furthermore, the rate of hesitation was significantly higher in CD patients (34/107; 32%) than in UC patients (38/188; 20%; p = 0.03).Patients considered that safety of medication (51%) and maintenance of remission (41%) was more important than receiving no treatment for IBD (19%) when planning to conceive. Mesalamine and infliximab were more favorable at conception than sulfasalazine and immunomodulators. Conclusions: This is the first report to survey the thinking of male IBD patients regarding pregnancy. Most male IBD patients considered "maintaining remission" as important at conception. Our study provides important information for IBD patients and for the treating physician when planning to conceive.

Original languageEnglish
Pages (from-to)183-188
Number of pages6
JournalJournal of Crohn's and Colitis
Volume4
Issue number2
DOIs
Publication statusPublished - 2010 Jun

Fingerprint

Inflammatory Bowel Diseases
Pregnancy
NSC 629243
Mesalamine
Sulfasalazine
Immunologic Factors
Live Birth
Patient Safety
Maintenance
Physicians

Keywords

  • Crohn's disease
  • Male IBD patients
  • Pregnancy
  • Ulcerative colitis

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Conception outcomes and opinions about pregnancy for men with inflammatory bowel disease. / Sato, Asaka; Naganuma, Makoto; Asakura, Keiko; Nishiwaki, Yuji; Yajima, Tomoharu; Hisamatsu, Tadakazu; Iwao, Yasushi; Takebayashi, Toru; Watanabe, Mamoru; Hibi, Toshifumi.

In: Journal of Crohn's and Colitis, Vol. 4, No. 2, 06.2010, p. 183-188.

Research output: Contribution to journalArticle

Sato, Asaka ; Naganuma, Makoto ; Asakura, Keiko ; Nishiwaki, Yuji ; Yajima, Tomoharu ; Hisamatsu, Tadakazu ; Iwao, Yasushi ; Takebayashi, Toru ; Watanabe, Mamoru ; Hibi, Toshifumi. / Conception outcomes and opinions about pregnancy for men with inflammatory bowel disease. In: Journal of Crohn's and Colitis. 2010 ; Vol. 4, No. 2. pp. 183-188.
@article{787e03dc71404d72897c113c7badf470,
title = "Conception outcomes and opinions about pregnancy for men with inflammatory bowel disease",
abstract = "Background and aims: Patients with inflammatory bowel disease (IBD) who want to have children are anxious to receive medical treatment. The consensus regarding pregnancy has not been surveyed for male IBD patients. The present study was investigated opinions among male IBD patients about pregnancy, conception and neonatal outcomes for partners. Methods: Subjects comprised 364 of 386 patients enrolled (94.3{\%}). Subjects received a questionnaire regarding their opinions and thoughts about pregnancy. The course of partner's conceptions and presence of neonatal malformations was also surveyed. Results: The rate of live births for partners of male IBD patients was 91.6{\%} (219/239). Most patients with CD (29/33; 88{\%}) had their children after surgery had been performed. The rate of expressing hopes to have a child tended to be higher for patients with UC (93/128; 73{\%}) than for patients with CD (61/97; 63{\%}; p = 0.21). Furthermore, the rate of hesitation was significantly higher in CD patients (34/107; 32{\%}) than in UC patients (38/188; 20{\%}; p = 0.03).Patients considered that safety of medication (51{\%}) and maintenance of remission (41{\%}) was more important than receiving no treatment for IBD (19{\%}) when planning to conceive. Mesalamine and infliximab were more favorable at conception than sulfasalazine and immunomodulators. Conclusions: This is the first report to survey the thinking of male IBD patients regarding pregnancy. Most male IBD patients considered {"}maintaining remission{"} as important at conception. Our study provides important information for IBD patients and for the treating physician when planning to conceive.",
keywords = "Crohn's disease, Male IBD patients, Pregnancy, Ulcerative colitis",
author = "Asaka Sato and Makoto Naganuma and Keiko Asakura and Yuji Nishiwaki and Tomoharu Yajima and Tadakazu Hisamatsu and Yasushi Iwao and Toru Takebayashi and Mamoru Watanabe and Toshifumi Hibi",
year = "2010",
month = "6",
doi = "10.1016/j.crohns.2009.10.004",
language = "English",
volume = "4",
pages = "183--188",
journal = "Journal of Crohn's and Colitis",
issn = "1873-9946",
publisher = "Elsevier",
number = "2",

}

TY - JOUR

T1 - Conception outcomes and opinions about pregnancy for men with inflammatory bowel disease

AU - Sato, Asaka

AU - Naganuma, Makoto

AU - Asakura, Keiko

AU - Nishiwaki, Yuji

AU - Yajima, Tomoharu

AU - Hisamatsu, Tadakazu

AU - Iwao, Yasushi

AU - Takebayashi, Toru

AU - Watanabe, Mamoru

AU - Hibi, Toshifumi

PY - 2010/6

Y1 - 2010/6

N2 - Background and aims: Patients with inflammatory bowel disease (IBD) who want to have children are anxious to receive medical treatment. The consensus regarding pregnancy has not been surveyed for male IBD patients. The present study was investigated opinions among male IBD patients about pregnancy, conception and neonatal outcomes for partners. Methods: Subjects comprised 364 of 386 patients enrolled (94.3%). Subjects received a questionnaire regarding their opinions and thoughts about pregnancy. The course of partner's conceptions and presence of neonatal malformations was also surveyed. Results: The rate of live births for partners of male IBD patients was 91.6% (219/239). Most patients with CD (29/33; 88%) had their children after surgery had been performed. The rate of expressing hopes to have a child tended to be higher for patients with UC (93/128; 73%) than for patients with CD (61/97; 63%; p = 0.21). Furthermore, the rate of hesitation was significantly higher in CD patients (34/107; 32%) than in UC patients (38/188; 20%; p = 0.03).Patients considered that safety of medication (51%) and maintenance of remission (41%) was more important than receiving no treatment for IBD (19%) when planning to conceive. Mesalamine and infliximab were more favorable at conception than sulfasalazine and immunomodulators. Conclusions: This is the first report to survey the thinking of male IBD patients regarding pregnancy. Most male IBD patients considered "maintaining remission" as important at conception. Our study provides important information for IBD patients and for the treating physician when planning to conceive.

AB - Background and aims: Patients with inflammatory bowel disease (IBD) who want to have children are anxious to receive medical treatment. The consensus regarding pregnancy has not been surveyed for male IBD patients. The present study was investigated opinions among male IBD patients about pregnancy, conception and neonatal outcomes for partners. Methods: Subjects comprised 364 of 386 patients enrolled (94.3%). Subjects received a questionnaire regarding their opinions and thoughts about pregnancy. The course of partner's conceptions and presence of neonatal malformations was also surveyed. Results: The rate of live births for partners of male IBD patients was 91.6% (219/239). Most patients with CD (29/33; 88%) had their children after surgery had been performed. The rate of expressing hopes to have a child tended to be higher for patients with UC (93/128; 73%) than for patients with CD (61/97; 63%; p = 0.21). Furthermore, the rate of hesitation was significantly higher in CD patients (34/107; 32%) than in UC patients (38/188; 20%; p = 0.03).Patients considered that safety of medication (51%) and maintenance of remission (41%) was more important than receiving no treatment for IBD (19%) when planning to conceive. Mesalamine and infliximab were more favorable at conception than sulfasalazine and immunomodulators. Conclusions: This is the first report to survey the thinking of male IBD patients regarding pregnancy. Most male IBD patients considered "maintaining remission" as important at conception. Our study provides important information for IBD patients and for the treating physician when planning to conceive.

KW - Crohn's disease

KW - Male IBD patients

KW - Pregnancy

KW - Ulcerative colitis

UR - http://www.scopus.com/inward/record.url?scp=77952100716&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77952100716&partnerID=8YFLogxK

U2 - 10.1016/j.crohns.2009.10.004

DO - 10.1016/j.crohns.2009.10.004

M3 - Article

C2 - 21122503

AN - SCOPUS:77952100716

VL - 4

SP - 183

EP - 188

JO - Journal of Crohn's and Colitis

JF - Journal of Crohn's and Colitis

SN - 1873-9946

IS - 2

ER -