Direct catalytic asymmetric aldol reaction of thioamide offers a new entry to the concise enantioselective synthesis of duloxetine. The direct aldol protocol was scalable (>20 g) to afford the aldol product in 92% ee after LiAlH 4 reduction, and 84% of the chiral ligand was recovered after recrystallization. The following four steps of transformation delivered duloxetine.
|Number of pages||5|
|Journal||Journal of Organic Chemistry|
|Publication status||Published - 2012 May 4|
ASJC Scopus subject areas
- Organic Chemistry