Concise synthesis of α-trisubstituted amines from ketones using n -methoxyamines

Yusuke Kurosaki; Kenji Shirokane; Takeshi Oishi; Takaaki Sato; Noritaka Chida

doi:10.1021/ol300622r

Concise synthesis of α-trisubstituted amines from ketones using n -methoxyamines

Yusuke Kurosaki, Kenji Shirokane, Takeshi Oishi, Takaaki Sato, Noritaka Chida

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Abstract

Three-component allylation and cyanation utilizing a ketone and an N-methoxyamine are reported. The high nucleophilicity of the N-methoxyamine and high electrophilicity of the corresponding iminium ion enable the concise synthesis of α-trisubstituted amines in a single step.

Original language	English
Pages (from-to)	2098-2101
Number of pages	4
Journal	Organic Letters
Volume	14
Issue number	8
DOIs	https://doi.org/10.1021/ol300622r
Publication status	Published - 2012 Apr 20

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol300622r

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title = "Concise synthesis of α-trisubstituted amines from ketones using n -methoxyamines",

abstract = "Three-component allylation and cyanation utilizing a ketone and an N-methoxyamine are reported. The high nucleophilicity of the N-methoxyamine and high electrophilicity of the corresponding iminium ion enable the concise synthesis of α-trisubstituted amines in a single step.",

author = "Yusuke Kurosaki and Kenji Shirokane and Takeshi Oishi and Takaaki Sato and Noritaka Chida",

year = "2012",

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language = "English",

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T1 - Concise synthesis of α-trisubstituted amines from ketones using n -methoxyamines

AU - Kurosaki, Yusuke

AU - Shirokane, Kenji

AU - Oishi, Takeshi

AU - Sato, Takaaki

AU - Chida, Noritaka

PY - 2012/4/20

Y1 - 2012/4/20

N2 - Three-component allylation and cyanation utilizing a ketone and an N-methoxyamine are reported. The high nucleophilicity of the N-methoxyamine and high electrophilicity of the corresponding iminium ion enable the concise synthesis of α-trisubstituted amines in a single step.

AB - Three-component allylation and cyanation utilizing a ketone and an N-methoxyamine are reported. The high nucleophilicity of the N-methoxyamine and high electrophilicity of the corresponding iminium ion enable the concise synthesis of α-trisubstituted amines in a single step.

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U2 - 10.1021/ol300622r

DO - 10.1021/ol300622r

M3 - Article

C2 - 22475208

AN - SCOPUS:84860161791

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SP - 2098

EP - 2101

JO - Organic Letters

JF - Organic Letters

IS - 8

ER -

Concise synthesis of α-trisubstituted amines from ketones using n -methoxyamines

Abstract

ASJC Scopus subject areas

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