Concise synthesis of α-trisubstituted amines from ketones using n -methoxyamines

Yusuke Kurosaki, Kenji Shirokane, Takeshi Oishi, Takaaki Satou, Noritaka Chida

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Three-component allylation and cyanation utilizing a ketone and an N-methoxyamine are reported. The high nucleophilicity of the N-methoxyamine and high electrophilicity of the corresponding iminium ion enable the concise synthesis of α-trisubstituted amines in a single step.

Original languageEnglish
Pages (from-to)2098-2101
Number of pages4
JournalOrganic Letters
Volume14
Issue number8
DOIs
Publication statusPublished - 2012 Apr 20

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Ketones
ketones
Amines
amines
Allylation
synthesis
ions
Ions
methoxyamine

ASJC Scopus subject areas

  • Organic Chemistry
  • Physical and Theoretical Chemistry
  • Biochemistry

Cite this

Concise synthesis of α-trisubstituted amines from ketones using n -methoxyamines. / Kurosaki, Yusuke; Shirokane, Kenji; Oishi, Takeshi; Satou, Takaaki; Chida, Noritaka.

In: Organic Letters, Vol. 14, No. 8, 20.04.2012, p. 2098-2101.

Research output: Contribution to journalArticle

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AU - Chida, Noritaka

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