Concise synthesis of α-trisubstituted amines from ketones using n -methoxyamines

Yusuke Kurosaki, Kenji Shirokane, Takeshi Oishi, Takaaki Sato, Noritaka Chida

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Three-component allylation and cyanation utilizing a ketone and an N-methoxyamine are reported. The high nucleophilicity of the N-methoxyamine and high electrophilicity of the corresponding iminium ion enable the concise synthesis of α-trisubstituted amines in a single step.

Original languageEnglish
Pages (from-to)2098-2101
Number of pages4
JournalOrganic Letters
Volume14
Issue number8
DOIs
Publication statusPublished - 2012 Apr 20

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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