Conjunctival injection reduction in patients with atopic keratoconjunctivitis due to synergic effect of bovine enteric-coated lactoferrin in 0.1% tacrolimus ophthalmic suspension

Hiroshi Fujishima, Naoko Okada, Kenji Matsumoto, Eisuke Shimizu, Shinji Fukuda, Masaru Tomita

Research output: Contribution to journalArticlepeer-review

Abstract

Lactoferrin (LF), a multifunctional glycoprotein found in mammalian milk, is reported to have immunoregulatory effects. The present study aimed to evaluate whether enteric-coated LF (eLF) could improve symptoms in patients with atopic keratoconjunctivitis (AKC). This randomized double-blind placebo-controlled single-center trial comprised Japanese patients (n = 20; aged 22–60 years) with AKC. Patients treated with 0.1% tacrolimus ophthalmic suspension (TALYMUS®) were administered eLF (400 mg/d of bovine LF) or placebo tablets for 12 weeks. Conjunctival injection was examined, papillae formation in the palpebral conjunctiva was evaluated, and corneal fluorescein score, itchy sensation in end-point itching scale, and serum allergic parameters were assessed. Conjunctival injection was significantly reduced in the LF group than in the placebo group (p = 0.0017, Mann–Whitney U-test). Papillae formation in the palpebral conjunctiva showed a statistical decrease in the LF group than in the placebo group (p = 0.010, unpaired T-test). LF combined with TALYMUS® could be a promising treatment strategy to mitigate AKC.

Original languageEnglish
Article number3093
Pages (from-to)1-9
Number of pages9
JournalJournal of Clinical Medicine
Volume9
Issue number10
DOIs
Publication statusPublished - 2020 Oct

Keywords

  • Atopic keratoconjunctivitis
  • Conjunctival injection
  • Lactoferrin
  • Tacrolimus ophthalmic suspension

ASJC Scopus subject areas

  • Medicine(all)

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