Conjunctival lymphoma arising from reactive lymphoid hyperplasia

Junichi Fukuhara, Satoru Kase, Mika Noda, Kan Ishijima, Teppei Yamamoto, Susumu Ishida

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Extra nodal marginal zone B-cell lymphoma (EMZL) of the conjunctiva typically arises in the marginal zone of mucosa-associated lymphoid tissue. The pathogenesis of conjunctival EMZL remains unknown. We describe an unusual case of EMZL arising from reactive lymphoid hyperplasia (RLH) of the conjunctiva. A 35-year-old woman had fleshy salmon-pink conjunctival tumors in both eyes, oculus uterque (OU). Specimens from conjunctival tumors in the right eye, oculus dexter (OD), revealed a collection of small lymphoid cells in the stroma. Immunohistochemically, immunoglobulin (Ig) light chain restriction was not detected. In contrast, diffuse atypical lymphoid cell infiltration was noted in the left eye, oculus sinister (OS), and positive for CD20, a marker for B cells OS. The tumors were histologically diagnosed as RLH OD, and EMZL OS. PCR analysis detected IgH gene rearrangement in the joining region (JH) region OU. After 11 months, a re-biopsy specimen demonstrated EMZL based on compatible pathological and genetic findings OD, arising from RLH. This case suggests that even if the diagnosis of the conjunctival lymphoproliferative lesions is histologically benign, confirmation of the B-cell clonality by checking IgH gene rearrangement should be useful to predict the incidence of malignancy.

Original languageEnglish
Article number194
JournalWorld Journal of Surgical Oncology
Volume10
DOIs
Publication statusPublished - 2012 Sep 18
Externally publishedYes

Fingerprint

Pseudolymphoma
Lymphoma
Gene Rearrangement
Conjunctiva
Neoplasms
B-Lymphocytes
Lymphocytes
Immunoglobulin Light Chains
Marginal Zone B-Cell Lymphoma
Salmon
Lymphoid Tissue
Mucous Membrane
Biopsy
Polymerase Chain Reaction
Incidence

Keywords

  • Conjunctiva
  • Extra nodal marginal zone B-cell lymphoma
  • Reactive lymphoid hyperplasia

ASJC Scopus subject areas

  • Oncology
  • Surgery

Cite this

Fukuhara, J., Kase, S., Noda, M., Ishijima, K., Yamamoto, T., & Ishida, S. (2012). Conjunctival lymphoma arising from reactive lymphoid hyperplasia. World Journal of Surgical Oncology, 10, [194]. https://doi.org/10.1186/1477-7819-10-194

Conjunctival lymphoma arising from reactive lymphoid hyperplasia. / Fukuhara, Junichi; Kase, Satoru; Noda, Mika; Ishijima, Kan; Yamamoto, Teppei; Ishida, Susumu.

In: World Journal of Surgical Oncology, Vol. 10, 194, 18.09.2012.

Research output: Contribution to journalArticle

Fukuhara, J, Kase, S, Noda, M, Ishijima, K, Yamamoto, T & Ishida, S 2012, 'Conjunctival lymphoma arising from reactive lymphoid hyperplasia', World Journal of Surgical Oncology, vol. 10, 194. https://doi.org/10.1186/1477-7819-10-194
Fukuhara, Junichi ; Kase, Satoru ; Noda, Mika ; Ishijima, Kan ; Yamamoto, Teppei ; Ishida, Susumu. / Conjunctival lymphoma arising from reactive lymphoid hyperplasia. In: World Journal of Surgical Oncology. 2012 ; Vol. 10.
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