Connectomics: comprehensive approaches for whole-brain mapping

Shinsuke Shibata, Yuji Komaki, Fumiko Seki, Michiko O. Inouye, Toshihiro Nagai, Hideyuki Okano

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The aim of connectomics analysis is to understand whole-brain neural connections. This is accomplished using new biotechnologies. Here, we provide an overview of the recent progress in connectomics analysis. The entire neural network of an organism was revealed for the first time in the nematode. Caenorhabditis elegans (C. elegans) have an advantage of their limited number of neurons and their transparency, allowing the neural network to be visualized using light and electron microscopes (EMs). It is practically impossible to adopt the same approach for mammals because of the large number of neural cells and the opacity of the central nervous system. A variety of new technologies are being developed to perform computer-assisted high-throughput image acquisition and analysis to obtain whole-brain maps for higher species, including mammals. Diffusion tensor magnetic resonance imaging and tractography and three-dimensional imaging with the EM are examples of novel approaches to connectomics. These new technologies will soon be applied not only to Drosophila, C. elegans and rodent research, but also to comprehensive connectomics analysis in a wide range of species including humans and primates. In the near future, results from connectomics analysis will reveal the neural circuitry of the whole brain and enhance our understanding of the human mind and neuropsychiatric diseases.

Original languageEnglish
Pages (from-to)57-67
Number of pages11
JournalMicroscopy
Volume64
Issue number1
DOIs
Publication statusPublished - 2015 Feb 1

Fingerprint

Connectome
Brain mapping
Brain Mapping
brain
Brain
mammals
Mammals
Electron microscopes
electron microscopes
primates
Neural networks
Drosophila
Caenorhabditis elegans
Imaging techniques
rodents
central nervous system
biotechnology
Image acquisition
Opacity
Neurology

Keywords

  • brain mapping
  • connectome
  • connectomics
  • electron microscope
  • magnetic resonance imaging
  • serial EM

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Connectomics : comprehensive approaches for whole-brain mapping. / Shibata, Shinsuke; Komaki, Yuji; Seki, Fumiko; Inouye, Michiko O.; Nagai, Toshihiro; Okano, Hideyuki.

In: Microscopy, Vol. 64, No. 1, 01.02.2015, p. 57-67.

Research output: Contribution to journalArticle

Shibata, Shinsuke ; Komaki, Yuji ; Seki, Fumiko ; Inouye, Michiko O. ; Nagai, Toshihiro ; Okano, Hideyuki. / Connectomics : comprehensive approaches for whole-brain mapping. In: Microscopy. 2015 ; Vol. 64, No. 1. pp. 57-67.
@article{cb67731fd1144743a34796c0935f65e8,
title = "Connectomics: comprehensive approaches for whole-brain mapping",
abstract = "The aim of connectomics analysis is to understand whole-brain neural connections. This is accomplished using new biotechnologies. Here, we provide an overview of the recent progress in connectomics analysis. The entire neural network of an organism was revealed for the first time in the nematode. Caenorhabditis elegans (C. elegans) have an advantage of their limited number of neurons and their transparency, allowing the neural network to be visualized using light and electron microscopes (EMs). It is practically impossible to adopt the same approach for mammals because of the large number of neural cells and the opacity of the central nervous system. A variety of new technologies are being developed to perform computer-assisted high-throughput image acquisition and analysis to obtain whole-brain maps for higher species, including mammals. Diffusion tensor magnetic resonance imaging and tractography and three-dimensional imaging with the EM are examples of novel approaches to connectomics. These new technologies will soon be applied not only to Drosophila, C. elegans and rodent research, but also to comprehensive connectomics analysis in a wide range of species including humans and primates. In the near future, results from connectomics analysis will reveal the neural circuitry of the whole brain and enhance our understanding of the human mind and neuropsychiatric diseases.",
keywords = "brain mapping, connectome, connectomics, electron microscope, magnetic resonance imaging, serial EM",
author = "Shinsuke Shibata and Yuji Komaki and Fumiko Seki and Inouye, {Michiko O.} and Toshihiro Nagai and Hideyuki Okano",
year = "2015",
month = "2",
day = "1",
doi = "10.1093/jmicro/dfu103",
language = "English",
volume = "64",
pages = "57--67",
journal = "Microscopy (Oxford, England)",
issn = "2050-5698",
publisher = "Japanese Society of Microscopy",
number = "1",

}

TY - JOUR

T1 - Connectomics

T2 - comprehensive approaches for whole-brain mapping

AU - Shibata, Shinsuke

AU - Komaki, Yuji

AU - Seki, Fumiko

AU - Inouye, Michiko O.

AU - Nagai, Toshihiro

AU - Okano, Hideyuki

PY - 2015/2/1

Y1 - 2015/2/1

N2 - The aim of connectomics analysis is to understand whole-brain neural connections. This is accomplished using new biotechnologies. Here, we provide an overview of the recent progress in connectomics analysis. The entire neural network of an organism was revealed for the first time in the nematode. Caenorhabditis elegans (C. elegans) have an advantage of their limited number of neurons and their transparency, allowing the neural network to be visualized using light and electron microscopes (EMs). It is practically impossible to adopt the same approach for mammals because of the large number of neural cells and the opacity of the central nervous system. A variety of new technologies are being developed to perform computer-assisted high-throughput image acquisition and analysis to obtain whole-brain maps for higher species, including mammals. Diffusion tensor magnetic resonance imaging and tractography and three-dimensional imaging with the EM are examples of novel approaches to connectomics. These new technologies will soon be applied not only to Drosophila, C. elegans and rodent research, but also to comprehensive connectomics analysis in a wide range of species including humans and primates. In the near future, results from connectomics analysis will reveal the neural circuitry of the whole brain and enhance our understanding of the human mind and neuropsychiatric diseases.

AB - The aim of connectomics analysis is to understand whole-brain neural connections. This is accomplished using new biotechnologies. Here, we provide an overview of the recent progress in connectomics analysis. The entire neural network of an organism was revealed for the first time in the nematode. Caenorhabditis elegans (C. elegans) have an advantage of their limited number of neurons and their transparency, allowing the neural network to be visualized using light and electron microscopes (EMs). It is practically impossible to adopt the same approach for mammals because of the large number of neural cells and the opacity of the central nervous system. A variety of new technologies are being developed to perform computer-assisted high-throughput image acquisition and analysis to obtain whole-brain maps for higher species, including mammals. Diffusion tensor magnetic resonance imaging and tractography and three-dimensional imaging with the EM are examples of novel approaches to connectomics. These new technologies will soon be applied not only to Drosophila, C. elegans and rodent research, but also to comprehensive connectomics analysis in a wide range of species including humans and primates. In the near future, results from connectomics analysis will reveal the neural circuitry of the whole brain and enhance our understanding of the human mind and neuropsychiatric diseases.

KW - brain mapping

KW - connectome

KW - connectomics

KW - electron microscope

KW - magnetic resonance imaging

KW - serial EM

UR - http://www.scopus.com/inward/record.url?scp=84946203891&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84946203891&partnerID=8YFLogxK

U2 - 10.1093/jmicro/dfu103

DO - 10.1093/jmicro/dfu103

M3 - Article

C2 - 25527636

AN - SCOPUS:84926174034

VL - 64

SP - 57

EP - 67

JO - Microscopy (Oxford, England)

JF - Microscopy (Oxford, England)

SN - 2050-5698

IS - 1

ER -