Consistent in-frame internal tandem duplications of BCOR characterize clear cell sarcoma of the kidney

Hitomi Ueno-Yokohata, Hajime Okita, Keiko Nakasato, Shingo Akimoto, Jun Ichi Hata, Tsugumichi Koshinaga, Masahiro Fukuzawa, Nobutaka Kiyokawa

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63 Citations (Scopus)

Abstract

Clear cell sarcoma of the kidney (CCSK) is one of the major pediatric renal neoplasms, but its associated genetic abnormalities are largely unknown. We identified internal tandem duplications in the BCOR gene (BCL6 corepressor) affecting the C terminus in 100% (20/20) of CCSK tumors but in none (0/193) of the other pediatric renal tumors. CCSK tumors expressed only an aberrant BCOR allele, indicating a close correlation between BCOR aberration and CCSK tumorigenesis.

Original languageEnglish
Pages (from-to)861-863
Number of pages3
JournalNature Genetics
Volume47
Issue number8
DOIs
Publication statusPublished - 2015 Aug 30

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Clear Cell Sarcoma
Kidney
Pediatrics
Co-Repressor Proteins
Neoplasms
Kidney Neoplasms
Carcinogenesis
Alleles
Genes

ASJC Scopus subject areas

  • Genetics

Cite this

Ueno-Yokohata, H., Okita, H., Nakasato, K., Akimoto, S., Hata, J. I., Koshinaga, T., ... Kiyokawa, N. (2015). Consistent in-frame internal tandem duplications of BCOR characterize clear cell sarcoma of the kidney. Nature Genetics, 47(8), 861-863. https://doi.org/10.1038/ng.3338

Consistent in-frame internal tandem duplications of BCOR characterize clear cell sarcoma of the kidney. / Ueno-Yokohata, Hitomi; Okita, Hajime; Nakasato, Keiko; Akimoto, Shingo; Hata, Jun Ichi; Koshinaga, Tsugumichi; Fukuzawa, Masahiro; Kiyokawa, Nobutaka.

In: Nature Genetics, Vol. 47, No. 8, 30.08.2015, p. 861-863.

Research output: Contribution to journalArticle

Ueno-Yokohata, H, Okita, H, Nakasato, K, Akimoto, S, Hata, JI, Koshinaga, T, Fukuzawa, M & Kiyokawa, N 2015, 'Consistent in-frame internal tandem duplications of BCOR characterize clear cell sarcoma of the kidney', Nature Genetics, vol. 47, no. 8, pp. 861-863. https://doi.org/10.1038/ng.3338
Ueno-Yokohata, Hitomi ; Okita, Hajime ; Nakasato, Keiko ; Akimoto, Shingo ; Hata, Jun Ichi ; Koshinaga, Tsugumichi ; Fukuzawa, Masahiro ; Kiyokawa, Nobutaka. / Consistent in-frame internal tandem duplications of BCOR characterize clear cell sarcoma of the kidney. In: Nature Genetics. 2015 ; Vol. 47, No. 8. pp. 861-863.
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