Constituents from Entada scandens with TRAIL-resistance Overcoming Activity

Firoj Ahmed, Kazufumi Toume, Naoki Ishikawa, Midori A. Arai, Samir K. Sadhu, Masami Ishibashi

Research output: Contribution to journalArticle

Abstract

Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) has emerged as a promising anticancer agent because of its ability to selectively kill tumor cells. But TRAIL-resistance is a major problem of its therapy. A search for compounds for abrogating TRAIL-resistance has, thus, become an important strategy for anticancer drug discovery. In search of bioactive natural products for overcoming TRAIL-resistance, we previously reported some compounds with TRAIL-resistance overcoming activity. Bioassay guided fractionation of Entada scandens led to the isolation of four compounds (1-4). Of the isolates, compounds 1 and 3 showed moderate TRAIL-resistance overcoming activity in TRAIL-resistant human gastric adenocarcinoma (AGS) cells.

Original languageEnglish
Pages (from-to)993-995
Number of pages3
JournalNatural product communications
Volume11
Issue number7
DOIs
Publication statusPublished - 2016

Keywords

  • Entada scandens
  • TRAIL-resistance overcoming activity

ASJC Scopus subject areas

  • Pharmacology
  • Plant Science
  • Drug Discovery
  • Complementary and alternative medicine

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