Constituents of Amoora cucullata with TRAIL resistance-overcoming activity

Firoj Ahmed, Kazufumi Toume, Samir K. Sadhu, Takashi Ohtsuki, Midori A. Arai, Masami Ishibashi

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

In search of bioactive natural products for overcoming TRAIL resistance from natural resources, we previously reported a number of active compounds. Bioassay-guided fractionation of mangrove, Amoora cucullata, collected from Sundarbans Mangrove Forest, Bangladesh, led to the isolation of four new compounds (1-4), along with seven known compounds (5-11). Of the isolates, compounds 1, 5, 8, and 9 showed TRAIL resistance-overcoming activity, among which 8 showed the most potent activity and enhanced TRAIL-induced apoptosis in TRAIL-resistant human gastric adenocarcinoma (AGS) cells through the activation of caspase-3/7, enhancing the expression of DR4 and DR5 mRNA in AGS cells. Cell death caused by the combined treatment of 8 and TRAIL was inhibited by human recombinant DR5/Fc and DR4/Fc chimera proteins, indicating that 8 sensitizes TRAIL-resistant AGS cells to TRAIL through the induction of DR4 and DR5.

Original languageEnglish
Pages (from-to)3696-3703
Number of pages8
JournalOrganic and Biomolecular Chemistry
Volume8
Issue number16
DOIs
Publication statusPublished - 2010 Aug 21
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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