In a search for natural products with activity to overcome tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistance, we performed the bioassay-guided fractionation of a semi mangrove, Pongamia pinnata, collected from Bangladesh, and isolated a new compound, (2S)-(2″,3″:7,8)- furanoflavanone (1), along with six known flavonoids (2-7). Two of the compounds significantly overcame TRAIL-resistance in human gastric adenocarcinoma (AGS) cell lines.
|Number of pages||3|
|Journal||Chemical and Pharmaceutical Bulletin|
|Publication status||Published - 2010 Nov|
- Pongamia pinnata
ASJC Scopus subject areas
- Drug Discovery