Constituents of Pongamia pinnata isolated in a screening for activity to overcome tumor necrosis factor-related apoptosis-inducing ligand-resistance

Tomohiro Minakawa, Kazufumi Toume, Firoj Ahmed, Samir Kumar Sadhu, Takashi Ohtsuki, Midori A. Arai, Masami Ishibashi

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

In a search for natural products with activity to overcome tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistance, we performed the bioassay-guided fractionation of a semi mangrove, Pongamia pinnata, collected from Bangladesh, and isolated a new compound, (2S)-(2″,3″:7,8)- furanoflavanone (1), along with six known flavonoids (2-7). Two of the compounds significantly overcame TRAIL-resistance in human gastric adenocarcinoma (AGS) cell lines.

Original languageEnglish
Pages (from-to)1549-1551
Number of pages3
JournalChemical and Pharmaceutical Bulletin
Volume58
Issue number11
DOIs
Publication statusPublished - 2010 Nov 1
Externally publishedYes

Keywords

  • Flavanone
  • Pongamia pinnata
  • Screening

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

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