Constituents of the Seed of Malva verticillata: VI: 1) Characterization and Immunological Activities of a Novel Acidic Polysaccharide

Haruki Yamada, Ryoko Gonda, Masashi Tomoda, Mieko Kanari, Noriko Shimizu

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

A novel acidic polysaccharide, designated as MVS-VI, was isolated from the seeds of Malva verticillata L. It was homogeneous on electrophoresis and gel chromatography, and its molecular mass was estimated to be 26000. It is composed of L-arabinose: D-xylose: D-galactose: D-glucose: L-rhamnose: D-galacturonic acid in the molar ratio of 30:15:20:3:2:10, in addition to small amounts of peptide moiety. Methylation analysis, carbon-13 nuclear magnetic resonance and periodate oxidation studies indicated its structural features to have mainly acidic α-arabino-3,6-β-galactan type structural units. MVS-VI showed significant reticuloendothelial system-potentiating activity in a carbon clearance test, and it possesses remarkable anti-complementary activity.

Original languageEnglish
Pages (from-to)2771-2774
Number of pages4
JournalChemical and Pharmaceutical Bulletin
Volume38
Issue number10
DOIs
Publication statusPublished - 1990

Keywords

  • MVS-VI
  • Malva verticillata
  • acidic arabinogalactan
  • anti-complementary activity
  • immunological activity
  • polysaccharide structure
  • reticuloendothelial system
  • seed

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

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