Abstract
(Chemical Equation Presented) Functionalization of the angular methine carbon of hydroxyproline-derived dioxopiperazines by a radical-promoted C-H bond oxidation, which is directed by a proximal (bromomethyl)silyl group, is described. This regioselective oxidation is the key step in a new synthesis of epidithiodioxopiperazines.
| Original language | English |
|---|---|
| Pages (from-to) | 5267-5270 |
| Number of pages | 4 |
| Journal | Organic Letters |
| Volume | 9 |
| Issue number | 25 |
| DOIs | |
| Publication status | Published - 2007 Dec 6 |
| Externally published | Yes |
ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry
Fingerprint Dive into the research topics of 'Construction of epidithiodioxopiperazines by directed oxidation of hydroxyproline-derived dioxopiperazines'. Together they form a unique fingerprint.
Cite this
Overman, L. E., & Sato, T. (2007). Construction of epidithiodioxopiperazines by directed oxidation of hydroxyproline-derived dioxopiperazines. Organic Letters, 9(25), 5267-5270. https://doi.org/10.1021/ol702518t