Construction of stable capillary networks using a microfluidic device

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Construction of stable capillary networks is required to provide sufficient oxygen and nutrients to the deep region of thick tissues, which is important in the context of 3D tissue engineering. Although conventional in vitro culture models have been used to investigate the mechanism of capillary formation, recent advances in microfluidics technologies allowed us to control biophysical and biochemical culture environments more precisely, which led to the construction of functional and stable capillary networks. In this study, endothelial cells and mesenchymal stem cells were co-cultured in microfluidic devices to construct stable capillary networks, which resulted in the construction of luminal structures covered by pericytes. Interactions between endothelial cells and mesenchymal stem cells are also discussed in the context of capillary formation.

Original languageEnglish
Title of host publicationProceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages350-353
Number of pages4
Volume2015-November
ISBN (Print)9781424492718
DOIs
Publication statusPublished - 2015 Nov 4
Event37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015 - Milan, Italy
Duration: 2015 Aug 252015 Aug 29

Other

Other37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015
CountryItaly
CityMilan
Period15/8/2515/8/29

Fingerprint

Lab-On-A-Chip Devices
Microfluidics
Endothelial cells
Stem cells
Mesenchymal Stromal Cells
Tissue engineering
Endothelial Cells
Nutrients
Pericytes
Tissue
Tissue Engineering
Oxygen
Technology
Food

ASJC Scopus subject areas

  • Computer Vision and Pattern Recognition
  • Signal Processing
  • Biomedical Engineering
  • Health Informatics

Cite this

Sudo, R. (2015). Construction of stable capillary networks using a microfluidic device. In Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS (Vol. 2015-November, pp. 350-353). [7318371] Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/EMBC.2015.7318371

Construction of stable capillary networks using a microfluidic device. / Sudo, Ryo.

Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS. Vol. 2015-November Institute of Electrical and Electronics Engineers Inc., 2015. p. 350-353 7318371.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Sudo, R 2015, Construction of stable capillary networks using a microfluidic device. in Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS. vol. 2015-November, 7318371, Institute of Electrical and Electronics Engineers Inc., pp. 350-353, 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015, Milan, Italy, 15/8/25. https://doi.org/10.1109/EMBC.2015.7318371
Sudo R. Construction of stable capillary networks using a microfluidic device. In Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS. Vol. 2015-November. Institute of Electrical and Electronics Engineers Inc. 2015. p. 350-353. 7318371 https://doi.org/10.1109/EMBC.2015.7318371
Sudo, Ryo. / Construction of stable capillary networks using a microfluidic device. Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS. Vol. 2015-November Institute of Electrical and Electronics Engineers Inc., 2015. pp. 350-353
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