Construction of the inbred strain

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Citations (Scopus)

Abstract

Genetically homogeneous populations such as inbred strains are valuable experimental tools in various fields of biomedical analyses. In many animals, inbred strains are established by consecutive sib-pair mating for a minimum of 20 generations. As the generation proceeds, fitness of the population reduces usually. Therefore, in order to establish inbred strains, the important point is the selection of pairs in good condition at each generation. Here, I describe the procedure and tips for generating inbred strains in zebrafish.

Original languageEnglish
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages107-118
Number of pages12
Volume1451
DOIs
Publication statusPublished - 2016

Publication series

NameMethods in Molecular Biology
Volume1451
ISSN (Print)10643745

Keywords

  • Genetic homogeneity
  • Inbred strain
  • Inbreeding depression
  • Polymorphisms
  • Sib-pair mating
  • Zebrafish

ASJC Scopus subject areas

  • Medicine(all)
  • Molecular Biology
  • Genetics

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  • Cite this

    Shinya, M. (2016). Construction of the inbred strain. In Methods in Molecular Biology (Vol. 1451, pp. 107-118). (Methods in Molecular Biology; Vol. 1451). Humana Press Inc.. https://doi.org/10.1007/978-1-4939-3771-4_8