Consumption of dairy products and death from cardiovascular disease in the Japanese General Population

The NIPPON DATA80

Imako Kondo, Toshiyuki Ojima, Mieko Nakamura, Shinya Hayasaka, Atsushi Hozawa, Shigeyuki Saitoh, Hirofumi Ohnishi, Hiroshi Akasaka, Takehito Hayakawa, Yoshitaka Murakami, Nagako Okuda, Katsuyuki Miura, Akira Okayama, Hirotsugu Ueshima, Tomonori Okamura, Kiyomi Sakata, Yosikazu Nakamura, Yasuhiro Matsumura, Nobuo Nishi, Fumiyoshi Kasagi & 10 others Toru Izumi, Koji Tamakoshi, Hideaki Nakagawa, Takayoshi Ohkubo, Yoshikuni Kita, Yasuyuki Nakamura, Katsushi Yoshita, Aya Kadota, Kazunori Kodama, Yutaka Kiyohara

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Background: Recent Western studies show an inverse association between milk and dairy product intake and cardiovascular disease (CVD). We studied the association between consumption of milk and dairy products and CVD death in Japan. Methods: Men and women aged 30 years or older were followed for 24 years. All had participated in a national nutrition survey in 300 health districts throughout Japan in 1980. The Cox proportional hazards model was used to assess mortality risk according to tertiles of milk and dairy product intake, with the high consumption group as reference. Hazard ratios (HRs) per 100-g/day increase in consumption were also estimated. Results: During the 24-year follow-up period, there were 893 CVD deaths, 174 deaths from coronary heart disease (CHD), and 417 stroke deaths among 9243 participants. For women, the HRs for death from CVD, CHD, and stroke in the low consumption group were 1.27 (95% CI: 0.99-1.58; P for trend = 0.045), 1.67 (0.99-2.80; P = 0.02), and 1.34 (0.94-1.90; P = 0.08), respectively, after adjustment for age, body mass index, smoking status, alcohol drinking habits, history of diabetes, use of antihypertensives, work category, and total energy intake. With each 100-g/day increase in consumption of milk and dairy products, HRs tended to decrease for deaths from CVD (HR, 0.86; 95% CI, 0.74-0.99), CHD (0.73; 0.52-1.03), and stroke (0.81; 0.65-1.01) in women. No significant association was observed in men. Conclusions: Consumption of milk and dairy products was inversely associated with CVD death among women in Japan.

Original languageEnglish
Pages (from-to)47-54
Number of pages8
JournalJournal of Epidemiology
Volume23
Issue number1
DOIs
Publication statusPublished - 2013

Fingerprint

Dairy Products
Cardiovascular Diseases
Milk
Population
Coronary Disease
Japan
Stroke
Nutrition Surveys
Energy Intake
Proportional Hazards Models
Alcohol Drinking
Antihypertensive Agents
Habits
Body Mass Index
Smoking
Mortality
Health

Keywords

  • Blood pressure
  • Cardiovascular disease
  • Coronary heart disease
  • Dairy products
  • Mortality

ASJC Scopus subject areas

  • Epidemiology

Cite this

Consumption of dairy products and death from cardiovascular disease in the Japanese General Population : The NIPPON DATA80. / Kondo, Imako; Ojima, Toshiyuki; Nakamura, Mieko; Hayasaka, Shinya; Hozawa, Atsushi; Saitoh, Shigeyuki; Ohnishi, Hirofumi; Akasaka, Hiroshi; Hayakawa, Takehito; Murakami, Yoshitaka; Okuda, Nagako; Miura, Katsuyuki; Okayama, Akira; Ueshima, Hirotsugu; Okamura, Tomonori; Sakata, Kiyomi; Nakamura, Yosikazu; Matsumura, Yasuhiro; Nishi, Nobuo; Kasagi, Fumiyoshi; Izumi, Toru; Tamakoshi, Koji; Nakagawa, Hideaki; Ohkubo, Takayoshi; Kita, Yoshikuni; Nakamura, Yasuyuki; Yoshita, Katsushi; Kadota, Aya; Kodama, Kazunori; Kiyohara, Yutaka.

In: Journal of Epidemiology, Vol. 23, No. 1, 2013, p. 47-54.

Research output: Contribution to journalArticle

Kondo, I, Ojima, T, Nakamura, M, Hayasaka, S, Hozawa, A, Saitoh, S, Ohnishi, H, Akasaka, H, Hayakawa, T, Murakami, Y, Okuda, N, Miura, K, Okayama, A, Ueshima, H, Okamura, T, Sakata, K, Nakamura, Y, Matsumura, Y, Nishi, N, Kasagi, F, Izumi, T, Tamakoshi, K, Nakagawa, H, Ohkubo, T, Kita, Y, Nakamura, Y, Yoshita, K, Kadota, A, Kodama, K & Kiyohara, Y 2013, 'Consumption of dairy products and death from cardiovascular disease in the Japanese General Population: The NIPPON DATA80', Journal of Epidemiology, vol. 23, no. 1, pp. 47-54. https://doi.org/10.2188/jea.JE20120054
Kondo, Imako ; Ojima, Toshiyuki ; Nakamura, Mieko ; Hayasaka, Shinya ; Hozawa, Atsushi ; Saitoh, Shigeyuki ; Ohnishi, Hirofumi ; Akasaka, Hiroshi ; Hayakawa, Takehito ; Murakami, Yoshitaka ; Okuda, Nagako ; Miura, Katsuyuki ; Okayama, Akira ; Ueshima, Hirotsugu ; Okamura, Tomonori ; Sakata, Kiyomi ; Nakamura, Yosikazu ; Matsumura, Yasuhiro ; Nishi, Nobuo ; Kasagi, Fumiyoshi ; Izumi, Toru ; Tamakoshi, Koji ; Nakagawa, Hideaki ; Ohkubo, Takayoshi ; Kita, Yoshikuni ; Nakamura, Yasuyuki ; Yoshita, Katsushi ; Kadota, Aya ; Kodama, Kazunori ; Kiyohara, Yutaka. / Consumption of dairy products and death from cardiovascular disease in the Japanese General Population : The NIPPON DATA80. In: Journal of Epidemiology. 2013 ; Vol. 23, No. 1. pp. 47-54.
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abstract = "Background: Recent Western studies show an inverse association between milk and dairy product intake and cardiovascular disease (CVD). We studied the association between consumption of milk and dairy products and CVD death in Japan. Methods: Men and women aged 30 years or older were followed for 24 years. All had participated in a national nutrition survey in 300 health districts throughout Japan in 1980. The Cox proportional hazards model was used to assess mortality risk according to tertiles of milk and dairy product intake, with the high consumption group as reference. Hazard ratios (HRs) per 100-g/day increase in consumption were also estimated. Results: During the 24-year follow-up period, there were 893 CVD deaths, 174 deaths from coronary heart disease (CHD), and 417 stroke deaths among 9243 participants. For women, the HRs for death from CVD, CHD, and stroke in the low consumption group were 1.27 (95{\%} CI: 0.99-1.58; P for trend = 0.045), 1.67 (0.99-2.80; P = 0.02), and 1.34 (0.94-1.90; P = 0.08), respectively, after adjustment for age, body mass index, smoking status, alcohol drinking habits, history of diabetes, use of antihypertensives, work category, and total energy intake. With each 100-g/day increase in consumption of milk and dairy products, HRs tended to decrease for deaths from CVD (HR, 0.86; 95{\%} CI, 0.74-0.99), CHD (0.73; 0.52-1.03), and stroke (0.81; 0.65-1.01) in women. No significant association was observed in men. Conclusions: Consumption of milk and dairy products was inversely associated with CVD death among women in Japan.",
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T1 - Consumption of dairy products and death from cardiovascular disease in the Japanese General Population

T2 - The NIPPON DATA80

AU - Kondo, Imako

AU - Ojima, Toshiyuki

AU - Nakamura, Mieko

AU - Hayasaka, Shinya

AU - Hozawa, Atsushi

AU - Saitoh, Shigeyuki

AU - Ohnishi, Hirofumi

AU - Akasaka, Hiroshi

AU - Hayakawa, Takehito

AU - Murakami, Yoshitaka

AU - Okuda, Nagako

AU - Miura, Katsuyuki

AU - Okayama, Akira

AU - Ueshima, Hirotsugu

AU - Okamura, Tomonori

AU - Sakata, Kiyomi

AU - Nakamura, Yosikazu

AU - Matsumura, Yasuhiro

AU - Nishi, Nobuo

AU - Kasagi, Fumiyoshi

AU - Izumi, Toru

AU - Tamakoshi, Koji

AU - Nakagawa, Hideaki

AU - Ohkubo, Takayoshi

AU - Kita, Yoshikuni

AU - Nakamura, Yasuyuki

AU - Yoshita, Katsushi

AU - Kadota, Aya

AU - Kodama, Kazunori

AU - Kiyohara, Yutaka

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N2 - Background: Recent Western studies show an inverse association between milk and dairy product intake and cardiovascular disease (CVD). We studied the association between consumption of milk and dairy products and CVD death in Japan. Methods: Men and women aged 30 years or older were followed for 24 years. All had participated in a national nutrition survey in 300 health districts throughout Japan in 1980. The Cox proportional hazards model was used to assess mortality risk according to tertiles of milk and dairy product intake, with the high consumption group as reference. Hazard ratios (HRs) per 100-g/day increase in consumption were also estimated. Results: During the 24-year follow-up period, there were 893 CVD deaths, 174 deaths from coronary heart disease (CHD), and 417 stroke deaths among 9243 participants. For women, the HRs for death from CVD, CHD, and stroke in the low consumption group were 1.27 (95% CI: 0.99-1.58; P for trend = 0.045), 1.67 (0.99-2.80; P = 0.02), and 1.34 (0.94-1.90; P = 0.08), respectively, after adjustment for age, body mass index, smoking status, alcohol drinking habits, history of diabetes, use of antihypertensives, work category, and total energy intake. With each 100-g/day increase in consumption of milk and dairy products, HRs tended to decrease for deaths from CVD (HR, 0.86; 95% CI, 0.74-0.99), CHD (0.73; 0.52-1.03), and stroke (0.81; 0.65-1.01) in women. No significant association was observed in men. Conclusions: Consumption of milk and dairy products was inversely associated with CVD death among women in Japan.

AB - Background: Recent Western studies show an inverse association between milk and dairy product intake and cardiovascular disease (CVD). We studied the association between consumption of milk and dairy products and CVD death in Japan. Methods: Men and women aged 30 years or older were followed for 24 years. All had participated in a national nutrition survey in 300 health districts throughout Japan in 1980. The Cox proportional hazards model was used to assess mortality risk according to tertiles of milk and dairy product intake, with the high consumption group as reference. Hazard ratios (HRs) per 100-g/day increase in consumption were also estimated. Results: During the 24-year follow-up period, there were 893 CVD deaths, 174 deaths from coronary heart disease (CHD), and 417 stroke deaths among 9243 participants. For women, the HRs for death from CVD, CHD, and stroke in the low consumption group were 1.27 (95% CI: 0.99-1.58; P for trend = 0.045), 1.67 (0.99-2.80; P = 0.02), and 1.34 (0.94-1.90; P = 0.08), respectively, after adjustment for age, body mass index, smoking status, alcohol drinking habits, history of diabetes, use of antihypertensives, work category, and total energy intake. With each 100-g/day increase in consumption of milk and dairy products, HRs tended to decrease for deaths from CVD (HR, 0.86; 95% CI, 0.74-0.99), CHD (0.73; 0.52-1.03), and stroke (0.81; 0.65-1.01) in women. No significant association was observed in men. Conclusions: Consumption of milk and dairy products was inversely associated with CVD death among women in Japan.

KW - Blood pressure

KW - Cardiovascular disease

KW - Coronary heart disease

KW - Dairy products

KW - Mortality

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