Continuous measurement of blood oxygen pressure using a fiber optic sensor based on phosphorescence quenching

Kentaro Hase, Shuhei Sakai, Kosuke Tsukada, Eiichi Sekizuka, Chikara Oshio, Haruyuki Minamitani

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Measuring oxygen pressure within an artery is essential for providing information on blood perfusion. Optic-sensor is particularly well suited for oxygen pressure measurement because electrolytic or magnetic changes of the environment do not affect the measurement. We developed a fiber optical sensor based on phosphorescence quenching method. The probe, Pd-meso-tetra(4-carboxyphenyl)porphyrin, was immobilized to the silicone resin membrane, which has high oxygen permeability, and attached to the tip of POF (outer diameter: 500μm). The light source used for exciting the probe was a Nd:YAG-SH pulse laser (532nm) and the phosphorescent emission was detected by a photomultiplier tube. The signal was fitted to a single exponential decay curve to acquire the time constant (life time), thereafter the oxygen pressure was calculated from Stern-Volmer relationship. Effectiveness of the sensor was obtained to measure the dissolved oxygen with high precision (correlation coefficient 0.999) and high response time (about 7sec). In this study, measurement of oxygen pressure was also made in femoral artery of rat by using the developed sensor and it indicated that it was very useful to measure arterial oxygen pressure continuously.

Original languageEnglish
Title of host publicationAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Pages1777-1778
Number of pages2
Volume2
Publication statusPublished - 2002
EventProceedings of the 2002 IEEE Engineering in Medicine and Biology 24th Annual Conference and the 2002 Fall Meeting of the Biomedical Engineering Society (BMES / EMBS) - Houston, TX, United States
Duration: 2002 Oct 232002 Oct 26

Other

OtherProceedings of the 2002 IEEE Engineering in Medicine and Biology 24th Annual Conference and the 2002 Fall Meeting of the Biomedical Engineering Society (BMES / EMBS)
CountryUnited States
CityHouston, TX
Period02/10/2302/10/26

Fingerprint

Phosphorescence
Fiber optic sensors
Quenching
Blood
Oxygen
Sensors
Photomultipliers
Porphyrins
Dissolved oxygen
Pressure measurement
Silicones
Light sources
Rats
Laser pulses
Optics
Membranes

Keywords

  • Fiber-optical sensor
  • Oxygen
  • Phosphorescence

ASJC Scopus subject areas

  • Bioengineering

Cite this

Hase, K., Sakai, S., Tsukada, K., Sekizuka, E., Oshio, C., & Minamitani, H. (2002). Continuous measurement of blood oxygen pressure using a fiber optic sensor based on phosphorescence quenching. In Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings (Vol. 2, pp. 1777-1778)

Continuous measurement of blood oxygen pressure using a fiber optic sensor based on phosphorescence quenching. / Hase, Kentaro; Sakai, Shuhei; Tsukada, Kosuke; Sekizuka, Eiichi; Oshio, Chikara; Minamitani, Haruyuki.

Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. Vol. 2 2002. p. 1777-1778.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Hase, K, Sakai, S, Tsukada, K, Sekizuka, E, Oshio, C & Minamitani, H 2002, Continuous measurement of blood oxygen pressure using a fiber optic sensor based on phosphorescence quenching. in Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. vol. 2, pp. 1777-1778, Proceedings of the 2002 IEEE Engineering in Medicine and Biology 24th Annual Conference and the 2002 Fall Meeting of the Biomedical Engineering Society (BMES / EMBS), Houston, TX, United States, 02/10/23.
Hase K, Sakai S, Tsukada K, Sekizuka E, Oshio C, Minamitani H. Continuous measurement of blood oxygen pressure using a fiber optic sensor based on phosphorescence quenching. In Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. Vol. 2. 2002. p. 1777-1778
Hase, Kentaro ; Sakai, Shuhei ; Tsukada, Kosuke ; Sekizuka, Eiichi ; Oshio, Chikara ; Minamitani, Haruyuki. / Continuous measurement of blood oxygen pressure using a fiber optic sensor based on phosphorescence quenching. Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. Vol. 2 2002. pp. 1777-1778
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