Continuous pulmonary perfusion during cardiopulmonary bypass prevents lung injury in infants

Takaaki Suzuki, Toyoki Fukuda, Tsutomu Ito, Yoshito Inoue, Yasunori Cho, Ichiro Kashima

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

Background. Lung injury after cardiopulmonary bypass is a serious complication for infants with congenital heart disease and pulmonary hypertension. Excessive neutrophil sequestration in the lung occurring after reestablishment of pulmonary circulation implies that interaction between neutrophils and pulmonary endothelium is the major cause of lung injury. Methods. Thirty infants with either ventricular septal defect or atrioventricular septal defect and with pulmonary hypertension were enrolled in this study. We performed continuous pulmonary perfusion during total cardiopulmonary bypass on 16 patients (perfused group) and conventional cardiopulmonary bypass on 14 patients (control group). PaO2/FiO2 and neutrophil counts were assessed from immediately before surgery to 24 hours after termination of cardiopulmonary bypass. Results. PaO2/FiO2 was higher in the perfused group than in the control group, and the difference was significant throughout the study period. Neutrophil counts decreased below prebypass values in both groups at 30 minutes after aortic unclamping, and the difference was significant in the control group but was not in the perfused group. Duration of postoperative ventilatory support was significantly less in the perfused group. Conclusions. Our study demonstrates that arrested pulmonary circulation during cardiopulmonary bypass is the major risk factor of lung injury and that continuous pulmonary perfusion is effective in preventing lung injury. (C) 2000 by The Society of Thoracic Surgeons.

Original languageEnglish
Pages (from-to)602-606
Number of pages5
JournalAnnals of Thoracic Surgery
Volume69
Issue number2
DOIs
Publication statusPublished - 2000 Feb
Externally publishedYes

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Lung Injury
Cardiopulmonary Bypass
Perfusion
Neutrophils
Lung
Pulmonary Circulation
Pulmonary Hypertension
Control Groups
Ventricular Heart Septal Defects
Endothelium
Heart Diseases

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery

Cite this

Continuous pulmonary perfusion during cardiopulmonary bypass prevents lung injury in infants. / Suzuki, Takaaki; Fukuda, Toyoki; Ito, Tsutomu; Inoue, Yoshito; Cho, Yasunori; Kashima, Ichiro.

In: Annals of Thoracic Surgery, Vol. 69, No. 2, 02.2000, p. 602-606.

Research output: Contribution to journalArticle

Suzuki, Takaaki ; Fukuda, Toyoki ; Ito, Tsutomu ; Inoue, Yoshito ; Cho, Yasunori ; Kashima, Ichiro. / Continuous pulmonary perfusion during cardiopulmonary bypass prevents lung injury in infants. In: Annals of Thoracic Surgery. 2000 ; Vol. 69, No. 2. pp. 602-606.
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