Continuous Separation Method with Liquid Particle Extractor: Enantioseparation of Mandelic Acid

Hideyuki Nishizawa, Kayoko Tahara, Aiko Hayashida, Yoshihiro Abe

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Continuous enantioseparation of (±)-mandelic acid was performed by dual-flow countercurrent extraction. The optimum extraction condition was calculated by a semi-empirical computational method. Use of the two-phase system composed of a 0.2 mM copper(II) acetate aqueous solution and butanol containing 10 mM JV-dodecyl-L-proline copper(II) complex as a chiral separator allowed (±)-mandelic acid to be separated continuously. HPLC analysis showed that the-form was extracted into the organic phase and the (+)-form was recovered from the aqueous extract with ee higher than 99.9%, at the stationary state.

Original languageEnglish
Pages (from-to)611-615
Number of pages5
Journalanalytical sciences
Issue number5
Publication statusPublished - 1993 Jan 1



  • (±)-mandelic acid
  • Enantioseparation
  • dual-flow countercurrent extraction
  • liquid particle extractor
  • optical resolution

ASJC Scopus subject areas

  • Analytical Chemistry

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