Continuous Separation Method with Liquid Particle Extractor: Enantioseparation of Mandelic Acid

Hideyuki Nishizawa, Kayoko Tahara, Aiko Hayashida, Yoshihiro Abe

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Continuous enantioseparation of (±)-mandelic acid was performed by dual-flow countercurrent extraction. The optimum extraction condition was calculated by a semi-empirical computational method. Use of the two-phase system composed of a 0.2 mM copper(II) acetate aqueous solution and butanol containing 10 mM JV-dodecyl-L-proline copper(II) complex as a chiral separator allowed (±)-mandelic acid to be separated continuously. HPLC analysis showed that the-form was extracted into the organic phase and the (+)-form was recovered from the aqueous extract with ee higher than 99.9%, at the stationary state.

Original languageEnglish
Pages (from-to)611-615
Number of pages5
JournalAnalytical Sciences
Volume9
Issue number5
DOIs
Publication statusPublished - 1993

Fingerprint

Butanols
Liquids
Computational methods
Separators
Proline
Copper
mandelic acid
cupric acetate

Keywords

  • (±)-mandelic acid
  • dual-flow countercurrent extraction
  • Enantioseparation
  • liquid particle extractor
  • optical resolution

ASJC Scopus subject areas

  • Analytical Chemistry

Cite this

Continuous Separation Method with Liquid Particle Extractor : Enantioseparation of Mandelic Acid. / Nishizawa, Hideyuki; Tahara, Kayoko; Hayashida, Aiko; Abe, Yoshihiro.

In: Analytical Sciences, Vol. 9, No. 5, 1993, p. 611-615.

Research output: Contribution to journalArticle

Nishizawa, Hideyuki ; Tahara, Kayoko ; Hayashida, Aiko ; Abe, Yoshihiro. / Continuous Separation Method with Liquid Particle Extractor : Enantioseparation of Mandelic Acid. In: Analytical Sciences. 1993 ; Vol. 9, No. 5. pp. 611-615.
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