Contribution of a peroxide adduct of copper(II)-peptide complex to modify the secondary structure of albumin

Yoshihiro Ishikawa, Sayo Ito, Satsohi Nishino, Shigeru Ohba, Yuzo Nishida

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

We have found that copper(II) compounds containing a peptide group in the chelate exhibit high activity for modification or degradation of albumin in the presence of hydrogen peroxide, whereas no activity was detected for the copper(II) compounds without an amide-group. It is suggested that presence of the amide-group in the ligand may play an important role in the formation of a peroxide adduct and in activation of the peroxide ion, leading to cleavage of the peptide bond of a neighboring protein. It is implied that conversion of normal cellular prion protein PrP(C) into a disease-causing isoform, PrP(Sc) is attributed to the activated peroxide ion coordinated to a copper(II) captured in the NH2-terminal domain of the PrP(C).

Original languageEnglish
Pages (from-to)378-382
Number of pages5
JournalZeitschrift fur Naturforschung - Section C Journal of Biosciences
Volume53
Issue number5-6
Publication statusPublished - 1998 May

Fingerprint

Peroxides
peroxides
Copper compounds
albumins
Copper
Albumins
copper
peptides
amides
Amides
Peptides
Ions
ions
prions
chelates
Protein C
Hydrogen Peroxide
hydrogen peroxide
Protein Isoforms
Chemical activation

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry

Cite this

Contribution of a peroxide adduct of copper(II)-peptide complex to modify the secondary structure of albumin. / Ishikawa, Yoshihiro; Ito, Sayo; Nishino, Satsohi; Ohba, Shigeru; Nishida, Yuzo.

In: Zeitschrift fur Naturforschung - Section C Journal of Biosciences, Vol. 53, No. 5-6, 05.1998, p. 378-382.

Research output: Contribution to journalArticle

Ishikawa, Yoshihiro ; Ito, Sayo ; Nishino, Satsohi ; Ohba, Shigeru ; Nishida, Yuzo. / Contribution of a peroxide adduct of copper(II)-peptide complex to modify the secondary structure of albumin. In: Zeitschrift fur Naturforschung - Section C Journal of Biosciences. 1998 ; Vol. 53, No. 5-6. pp. 378-382.
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