TY - JOUR
T1 - Contribution of an affect-associated gene to human longevity
T2 - Prevalence of the long-allele genotype of the serotonin transporter-linked gene in Japanese centenarians
AU - Gondo, Yasuyuki
AU - Hirose, Nobuyoshi
AU - Arai, Yasumichi
AU - Yamamura, Ken
AU - Shimizu, Ken Ichirou
AU - Takayama, Michiyo
AU - Ebihara, Yoshinori
AU - Nakazawa, Susumu
AU - Inagaki, Hiroki
AU - Masui, Yukie
AU - Kitagawa, Koji
N1 - Funding Information:
This study was partly supported by a grant from the Japanese Ministry of Health and Welfare for the Scientific Research Project on Longevity, a grant for studying the sociomedical background of centenarians (Principal Investigator, Nobuyoshi Hirose), a grant from the Japanese Ministry of Education, Science and Culture (No. 15730346, Yasuyuki Gondo), and aid for research from the Keio Health Consulting Center.
PY - 2005/11
Y1 - 2005/11
N2 - Negative affect such as depression and anxiety has been reported to be associated with morbidity and mortality, and polymorphisms of the serotonin transporter (5HTT) gene may be associated with such affect disorders. Hypothesizing that 5HTT gene polymorphisms could influence human longevity via negative affect; we compared the polymorphic variation of the 5HTT gene between 265 Japanese centenarians and control subjects. In addition, we evaluated the relationships between the 5HTT genotype and the physical, cognitive, and biologic status of centenarians, as indicated by the Barthel Index, the Mini-Mental State Examination, and serum albumin concentration, respectively. The frequency of the l/l genotype and the l allele was significantly greater in centenarians than in younger control subjects, particularly women. A significant effect of the 5HTT genotype on serum albumin concentration was observed in both sexes. Although, there was sex optionality, the l allele may carry a longevity advantage possibly through behavioral mechanisms.
AB - Negative affect such as depression and anxiety has been reported to be associated with morbidity and mortality, and polymorphisms of the serotonin transporter (5HTT) gene may be associated with such affect disorders. Hypothesizing that 5HTT gene polymorphisms could influence human longevity via negative affect; we compared the polymorphic variation of the 5HTT gene between 265 Japanese centenarians and control subjects. In addition, we evaluated the relationships between the 5HTT genotype and the physical, cognitive, and biologic status of centenarians, as indicated by the Barthel Index, the Mini-Mental State Examination, and serum albumin concentration, respectively. The frequency of the l/l genotype and the l allele was significantly greater in centenarians than in younger control subjects, particularly women. A significant effect of the 5HTT genotype on serum albumin concentration was observed in both sexes. Although, there was sex optionality, the l allele may carry a longevity advantage possibly through behavioral mechanisms.
KW - Centenarians
KW - Gender difference
KW - Longevity
KW - Serotonin transporter gene-linked polymorphism region
KW - Serum albumin
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U2 - 10.1016/j.mad.2005.06.006
DO - 10.1016/j.mad.2005.06.006
M3 - Article
C2 - 16095668
AN - SCOPUS:25144518559
VL - 126
SP - 1178
EP - 1184
JO - Mechanisms of Ageing and Development
JF - Mechanisms of Ageing and Development
SN - 0047-6374
IS - 11
ER -
