Contribution of developmental changes in energy metabolism to excitation-contraction coupling of a ventricular cell

A simulation study

Hitomi I. Sano, Tamami Toki, Yasuhiro Naito, Masaru Tomita

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

In fetal guinea pigs, ventricular cells have higher anaerobic glycolytic capacity and lower mitochondrial enzyme activity. Here, we implemented developmental changes in glycolytic enzyme activity, concentrations of glycogen, and total creatine in late embryonic and adult ventricular cell models. We then simulated the effects of hypoxic conditions on dynamic changes in contractile force and ATP concentration. Our model demonstrates that fetal ventricular cells maintain ATP for longer periods of time than adult ventricular cells. This is consistent with reported dynamics of ventricular cells under hypoxic conditions.

Original languageEnglish
Title of host publicationComputing in Cardiology
PublisherIEEE Computer Society
Pages73-76
Number of pages4
Volume41
EditionJanuary
Publication statusPublished - 2014
Event41st Computing in Cardiology Conference, CinC 2014 - Cambridge, United States
Duration: 2014 Sep 72014 Sep 10

Other

Other41st Computing in Cardiology Conference, CinC 2014
CountryUnited States
CityCambridge
Period14/9/714/9/10

Fingerprint

Excitation Contraction Coupling
Adenosinetriphosphate
Enzyme activity
Energy Metabolism
Adenosine Triphosphate
Creatine
Enzymes
Glycogen
Guinea Pigs

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Computer Science(all)

Cite this

Sano, H. I., Toki, T., Naito, Y., & Tomita, M. (2014). Contribution of developmental changes in energy metabolism to excitation-contraction coupling of a ventricular cell: A simulation study. In Computing in Cardiology (January ed., Vol. 41, pp. 73-76). [7042982] IEEE Computer Society.

Contribution of developmental changes in energy metabolism to excitation-contraction coupling of a ventricular cell : A simulation study. / Sano, Hitomi I.; Toki, Tamami; Naito, Yasuhiro; Tomita, Masaru.

Computing in Cardiology. Vol. 41 January. ed. IEEE Computer Society, 2014. p. 73-76 7042982.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Sano, HI, Toki, T, Naito, Y & Tomita, M 2014, Contribution of developmental changes in energy metabolism to excitation-contraction coupling of a ventricular cell: A simulation study. in Computing in Cardiology. January edn, vol. 41, 7042982, IEEE Computer Society, pp. 73-76, 41st Computing in Cardiology Conference, CinC 2014, Cambridge, United States, 14/9/7.
Sano HI, Toki T, Naito Y, Tomita M. Contribution of developmental changes in energy metabolism to excitation-contraction coupling of a ventricular cell: A simulation study. In Computing in Cardiology. January ed. Vol. 41. IEEE Computer Society. 2014. p. 73-76. 7042982
Sano, Hitomi I. ; Toki, Tamami ; Naito, Yasuhiro ; Tomita, Masaru. / Contribution of developmental changes in energy metabolism to excitation-contraction coupling of a ventricular cell : A simulation study. Computing in Cardiology. Vol. 41 January. ed. IEEE Computer Society, 2014. pp. 73-76
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