Contribution of developmental changes in energy metabolism to excitation-contraction coupling of a ventricular cell: A simulation study

Hitomi I. Sano, Tamami Toki, Yasuhiro Naito, Masaru Tomita

Research output: Contribution to journalConference article

Abstract

In fetal guinea pigs, ventricular cells have higher anaerobic glycolytic capacity and lower mitochondrial enzyme activity. Here, we implemented developmental changes in glycolytic enzyme activity, concentrations of glycogen, and total creatine in late embryonic and adult ventricular cell models. We then simulated the effects of hypoxic conditions on dynamic changes in contractile force and ATP concentration. Our model demonstrates that fetal ventricular cells maintain ATP for longer periods of time than adult ventricular cells. This is consistent with reported dynamics of ventricular cells under hypoxic conditions.

Original languageEnglish
Article number7042982
Pages (from-to)73-76
Number of pages4
JournalComputing in Cardiology
Volume41
Issue numberJanuary
Publication statusPublished - 2014 Jan 1
Event41st Computing in Cardiology Conference, CinC 2014 - Cambridge, United States
Duration: 2014 Sep 72014 Sep 10

ASJC Scopus subject areas

  • Computer Science(all)
  • Cardiology and Cardiovascular Medicine

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