Contribution of Irf-1 promoter polymorphisms to the Th1-type cell response and interferon-β monotherapy for chronic hepatitis C

Hidetsugu Saito, Shinichiro Tada, Nobuhiro Nakamoto, Kumi Kitamura, Hiromi Horikawa, Satoshi Kurita, Hirotoshi Ebinuma, Hiromasa Ishii, Masahiko Takahashi, Shin Tanaka, Toshifumi Hibi

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Abstract

We recently reported promoter polymorphisms in the IRF-1 gene, an interferon-inducible gene that plays an important role in host antiviral function. The promoter activity was shown to be different between different polymorphisms. In this study, we investigated the relationship between IRF-1 promoter polymorphisms and the response to interferon monotherapy for chronic hepatitis C. Eighteen patients with a low initial viral load or hepatitis C virus (HCV) genotype non-1b received 6-months course of interferon-β monotherapy. IRF-1 gene mutations and the treatment response were investigated. The IRF-1 promoter type possessing a higher promoter activity (-415C/-410A/-300A) was found in only three patients, all of which had a lower viral load than those with other promoter types and were able to obtain a sustained viral response. Flow cytometric analysis of peripheral blood mononuclear cells showed that the patients with a higher promoter activity of the IRF-1 had a significantly higher proportion of T helper 1-type CD4+ cells after interferon administration than those of other promoter types. These results suggest that IRF-1 promoter polymorphisms may contribute, at least partially, to host antiviral activity for chronic hepatitis C.

Original languageEnglish
Pages (from-to)25-32
Number of pages8
JournalHepatology Research
Volume32
Issue number1
DOIs
Publication statusPublished - 2005 May 1

Keywords

  • Host immunological activity
  • Interferon monotherapy
  • Interferon regulatory factor
  • Promoter polymorphims
  • Response

ASJC Scopus subject areas

  • Hepatology
  • Infectious Diseases

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    Saito, H., Tada, S., Nakamoto, N., Kitamura, K., Horikawa, H., Kurita, S., Ebinuma, H., Ishii, H., Takahashi, M., Tanaka, S., & Hibi, T. (2005). Contribution of Irf-1 promoter polymorphisms to the Th1-type cell response and interferon-β monotherapy for chronic hepatitis C. Hepatology Research, 32(1), 25-32. https://doi.org/10.1016/j.hepres.2005.03.009