Control in mineralization by the polysaccharide-coated liposome via the counter-diffusion of ions

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

We created an organic-inorganic hybrid nanocapsule by utilizing polysaccharide-coated liposomes as a reaction site for the deposition of calcium phosphate (CaP). Phosphate ions were encapsulated in a liposome, followed by the layer-by-layer deposition of chitosan (CHI), dextran sulfate (DXS), or DNA onto the liposome surface. Calcium ions were added to an aqueous suspension of the phosphate ion-incorporated nanocapsules to prepare the nanocapsules that provide a variety of walls for the counter-diffusion of ions and the surface for CaP deposition. As a result, control in biomineralization, such as thickness and crystal properties, over the nanocapsules was achieved by tuning the counter-diffusion of the calcium ions and the phosphate ions through the capsule wall and the surface chemical composition of nanocapsules. Furthermore, we carried out DNA adsorption onto CaP-coated liposomes. DNA was releasable from the nanocapsules because of the dissolution of CaP under acidic conditions.

Original languageEnglish
Pages (from-to)4701-4708
Number of pages8
JournalChemistry of Materials
Volume23
Issue number21
DOIs
Publication statusPublished - 2011 Nov 8

Fingerprint

Nanocapsules
Liposomes
Polysaccharides
Calcium phosphate
Ions
Phosphates
DNA
Calcium
Biomineralization
Dextran Sulfate
Dextran
Chitosan
Capsules
Suspensions
Dissolution
Tuning
Adsorption
Crystals
calcium phosphate
Chemical analysis

Keywords

  • calcium phosphate
  • DNA
  • layer-by-layer deposition
  • Liposome
  • nanocapsule
  • organic-inorganic hybrid
  • polysaccharide

ASJC Scopus subject areas

  • Materials Chemistry
  • Chemical Engineering(all)
  • Chemistry(all)

Cite this

Control in mineralization by the polysaccharide-coated liposome via the counter-diffusion of ions. / Fukui, Yuuka; Fujimoto, Keiji.

In: Chemistry of Materials, Vol. 23, No. 21, 08.11.2011, p. 4701-4708.

Research output: Contribution to journalArticle

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