Control mechanism of JAK/STAT signal transduction pathway

Satoshi Yamada; Satoru Shiono; Akiko Joo; Akihiko Yoshimura

doi:10.1016/S0014-5793(02)03842-5

Control mechanism of JAK/STAT signal transduction pathway

Satoshi Yamada, Satoru Shiono, Akiko Joo, Akihiko Yoshimura

Research output: Contribution to journal › Article › peer-review

101 Citations (Scopus)

Abstract

Suppressor of cytokine signaling-1 (SOCS1) was identified as the negative regulator of Janus kinase (JAK) and signal transducer and activator of transcription (STAT) signal transduction pathway. However, the kinetics and control mechanism of the pathway have not yet been fully understood. We have developed the computer simulation of the JAK/STAT pathway. Without nuclear phosphatase, SOCS1's binding to JAK did not cause the decrease in nuclear phosphorylated STAT1. However, without SH2 domain-containing tyrosine phosphatase 2 (SHP-2) or cytoplasmic phosphatase, it did. So nuclear phosphatase is considered to be the most important in this system. By changing parameters of the model, dynamical characteristics and control mechanism were investigated.

Original language	English
Pages (from-to)	190-196
Number of pages	7
Journal	FEBS Letters
Volume	534
Issue number	1-3
DOIs	https://doi.org/10.1016/S0014-5793(02)03842-5
Publication status	Published - 2003 Jan 16
Externally published	Yes

Keywords

Interferon-γ
Janus kinase
Nuclear tyrosine phosphatase
Signal transducer and activator of transcription
Suppressor of cytokine signaling-1

ASJC Scopus subject areas

Biophysics
Structural Biology
Biochemistry
Molecular Biology
Genetics
Cell Biology

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10.1016/S0014-5793(02)03842-5

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title = "Control mechanism of JAK/STAT signal transduction pathway",

abstract = "Suppressor of cytokine signaling-1 (SOCS1) was identified as the negative regulator of Janus kinase (JAK) and signal transducer and activator of transcription (STAT) signal transduction pathway. However, the kinetics and control mechanism of the pathway have not yet been fully understood. We have developed the computer simulation of the JAK/STAT pathway. Without nuclear phosphatase, SOCS1's binding to JAK did not cause the decrease in nuclear phosphorylated STAT1. However, without SH2 domain-containing tyrosine phosphatase 2 (SHP-2) or cytoplasmic phosphatase, it did. So nuclear phosphatase is considered to be the most important in this system. By changing parameters of the model, dynamical characteristics and control mechanism were investigated.",

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AU - Yamada, Satoshi

AU - Shiono, Satoru

AU - Joo, Akiko

AU - Yoshimura, Akihiko

PY - 2003/1/16

Y1 - 2003/1/16

N2 - Suppressor of cytokine signaling-1 (SOCS1) was identified as the negative regulator of Janus kinase (JAK) and signal transducer and activator of transcription (STAT) signal transduction pathway. However, the kinetics and control mechanism of the pathway have not yet been fully understood. We have developed the computer simulation of the JAK/STAT pathway. Without nuclear phosphatase, SOCS1's binding to JAK did not cause the decrease in nuclear phosphorylated STAT1. However, without SH2 domain-containing tyrosine phosphatase 2 (SHP-2) or cytoplasmic phosphatase, it did. So nuclear phosphatase is considered to be the most important in this system. By changing parameters of the model, dynamical characteristics and control mechanism were investigated.

AB - Suppressor of cytokine signaling-1 (SOCS1) was identified as the negative regulator of Janus kinase (JAK) and signal transducer and activator of transcription (STAT) signal transduction pathway. However, the kinetics and control mechanism of the pathway have not yet been fully understood. We have developed the computer simulation of the JAK/STAT pathway. Without nuclear phosphatase, SOCS1's binding to JAK did not cause the decrease in nuclear phosphorylated STAT1. However, without SH2 domain-containing tyrosine phosphatase 2 (SHP-2) or cytoplasmic phosphatase, it did. So nuclear phosphatase is considered to be the most important in this system. By changing parameters of the model, dynamical characteristics and control mechanism were investigated.

KW - Interferon-γ

KW - Janus kinase

KW - Nuclear tyrosine phosphatase

KW - Signal transducer and activator of transcription

KW - Suppressor of cytokine signaling-1

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Control mechanism of JAK/STAT signal transduction pathway

Abstract

Keywords

ASJC Scopus subject areas

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