Control of product selectivity by a styrene additive in ruthenium-catalyzed C-H arylation

Shun Hiroshima, Daiki Matsumura, Takuya Kochi, Fumitoshi Kakiuchi

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

A unique effect of styrene additive on product selectivity was observed for RuH2(CO)(PPh3)3-catalyzed C-H arylation of acetophenone derivatives bearing two ortho C-H bonds. Without styrene, the C-H arylation with arylboronates gives diarylation products as the major products throughout the reaction, but the use of styrene as an additive switches the product selectivity and leads to selective formation of monoarylation products.

Original languageEnglish
Pages (from-to)5318-5321
Number of pages4
JournalOrganic Letters
Volume12
Issue number22
DOIs
Publication statusPublished - 2010 Nov 19

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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