Control of telomerase function on SPR sensor using polymer particles

Ryuji Hara, Kazunobu Toshima, Haruma Kawaguchi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The interaction of G-quadruplex (G4) DNA with telomerase inhibitors was investigated using SPR sensor. SPR signal was enhanced with polymer particle on which inhibitor was immobilized. The relation among molecular structure of inhibitors, inhibition activity and the effect of polymer particles was discussed. And we also evaluated stabilization ability of G4 by SPR signal of annealing between G4 and telomerase RNA (tR). The results suggested polymer particle led to SPR signal enhancement of interaction between G4 and telomerase inhibitors and the property of inhibitors immobilized on particle was unchanged.

Original languageEnglish
Title of host publicationPolymer Preprints, Japan
Pages2174
Number of pages1
Volume55
Edition1
Publication statusPublished - 2006
Event55th SPSJ Annual Meeting - Nagoya, Japan
Duration: 2006 May 242006 May 26

Other

Other55th SPSJ Annual Meeting
CountryJapan
CityNagoya
Period06/5/2406/5/26

Fingerprint

Sensors
Polymers
RNA
Molecular structure
DNA
Stabilization
Annealing

Keywords

  • Ethidium bromide
  • Polymer particle
  • SPR (surface plasmon resonance)
  • Telomerase inhibitor
  • Telomere

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Hara, R., Toshima, K., & Kawaguchi, H. (2006). Control of telomerase function on SPR sensor using polymer particles. In Polymer Preprints, Japan (1 ed., Vol. 55, pp. 2174)

Control of telomerase function on SPR sensor using polymer particles. / Hara, Ryuji; Toshima, Kazunobu; Kawaguchi, Haruma.

Polymer Preprints, Japan. Vol. 55 1. ed. 2006. p. 2174.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Hara, R, Toshima, K & Kawaguchi, H 2006, Control of telomerase function on SPR sensor using polymer particles. in Polymer Preprints, Japan. 1 edn, vol. 55, pp. 2174, 55th SPSJ Annual Meeting, Nagoya, Japan, 06/5/24.
Hara R, Toshima K, Kawaguchi H. Control of telomerase function on SPR sensor using polymer particles. In Polymer Preprints, Japan. 1 ed. Vol. 55. 2006. p. 2174
Hara, Ryuji ; Toshima, Kazunobu ; Kawaguchi, Haruma. / Control of telomerase function on SPR sensor using polymer particles. Polymer Preprints, Japan. Vol. 55 1. ed. 2006. pp. 2174
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