Abstract
The interaction of G-quadruplex (G4) DNA with telomerase inhibitors was investigated using SPR sensor. SPR signal was enhanced with polymer particle on which inhibitor was immobilized. The relation among molecular structure of inhibitors, inhibition activity and the effect of polymer particles was discussed. And we also evaluated stabilization ability of G4 by SPR signal of annealing between G4 and telomerase RNA (tR). The results suggested polymer particle led to SPR signal enhancement of interaction between G4 and telomerase inhibitors and the property of inhibitors immobilized on particle was unchanged.
| Original language | English |
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| Number of pages | 1 |
| Publication status | Published - 2006 Oct 19 |
| Event | 55th SPSJ Annual Meeting - Nagoya, Japan Duration: 2006 May 24 → 2006 May 26 |
Other
| Other | 55th SPSJ Annual Meeting |
|---|---|
| Country | Japan |
| City | Nagoya |
| Period | 06/5/24 → 06/5/26 |
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Keywords
- Ethidium bromide
- Polymer particle
- SPR (surface plasmon resonance)
- Telomerase inhibitor
- Telomere
ASJC Scopus subject areas
- Engineering(all)
Cite this
Hara, R., Toshima, K., & Kawaguchi, H. (2006). Control of telomerase function on SPR sensor using polymer particles. Paper presented at 55th SPSJ Annual Meeting, Nagoya, Japan.