Abstract
The interaction of G-quadruplex (G4) DNA with telomerase inhibitors was investigated using SPR sensor. SPR signal was enhanced with polymer particle on which inhibitor was immobilized. The relation among molecular structure of inhibitors, inhibition activity and the effect of polymer particles was discussed. And we also evaluated stabilization ability of G4 by SPR signal of annealing between G4 and telomerase RNA (tR). The results suggested polymer particle led to SPR signal enhancement of interaction between G4 and telomerase inhibitors and the property of inhibitors immobilized on particle was unchanged.
| Original language | English |
|---|---|
| Title of host publication | Polymer Preprints, Japan |
| Pages | 2174 |
| Number of pages | 1 |
| Volume | 55 |
| Edition | 1 |
| Publication status | Published - 2006 |
| Event | 55th SPSJ Annual Meeting - Nagoya, Japan Duration: 2006 May 24 → 2006 May 26 |
Other
| Other | 55th SPSJ Annual Meeting |
|---|---|
| Country | Japan |
| City | Nagoya |
| Period | 06/5/24 → 06/5/26 |
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Keywords
- Ethidium bromide
- Polymer particle
- SPR (surface plasmon resonance)
- Telomerase inhibitor
- Telomere
ASJC Scopus subject areas
- Engineering(all)
Cite this
Control of telomerase function on SPR sensor using polymer particles. / Hara, Ryuji; Toshima, Kazunobu; Kawaguchi, Haruma.
Polymer Preprints, Japan. Vol. 55 1. ed. 2006. p. 2174.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - Control of telomerase function on SPR sensor using polymer particles
AU - Hara, Ryuji
AU - Toshima, Kazunobu
AU - Kawaguchi, Haruma
PY - 2006
Y1 - 2006
N2 - The interaction of G-quadruplex (G4) DNA with telomerase inhibitors was investigated using SPR sensor. SPR signal was enhanced with polymer particle on which inhibitor was immobilized. The relation among molecular structure of inhibitors, inhibition activity and the effect of polymer particles was discussed. And we also evaluated stabilization ability of G4 by SPR signal of annealing between G4 and telomerase RNA (tR). The results suggested polymer particle led to SPR signal enhancement of interaction between G4 and telomerase inhibitors and the property of inhibitors immobilized on particle was unchanged.
AB - The interaction of G-quadruplex (G4) DNA with telomerase inhibitors was investigated using SPR sensor. SPR signal was enhanced with polymer particle on which inhibitor was immobilized. The relation among molecular structure of inhibitors, inhibition activity and the effect of polymer particles was discussed. And we also evaluated stabilization ability of G4 by SPR signal of annealing between G4 and telomerase RNA (tR). The results suggested polymer particle led to SPR signal enhancement of interaction between G4 and telomerase inhibitors and the property of inhibitors immobilized on particle was unchanged.
KW - Ethidium bromide
KW - Polymer particle
KW - SPR (surface plasmon resonance)
KW - Telomerase inhibitor
KW - Telomere
UR - http://www.scopus.com/inward/record.url?scp=33749851842&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33749851842&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:33749851842
VL - 55
SP - 2174
BT - Polymer Preprints, Japan
ER -