Control of telomerase function on SPR sensor using polymer particles

Ryuji Hara; Kazunobu Toshima; Haruma Kawaguchi

Control of telomerase function on SPR sensor using polymer particles

Ryuji Hara, Kazunobu Toshima, Haruma Kawaguchi

Department of Applied Chemistry

Research output: Contribution to conference › Paper › peer-review

Abstract

The interaction of G-quadruplex (G4) DNA with telomerase inhibitors was investigated using SPR sensor. SPR signal was enhanced with polymer particle on which inhibitor was immobilized. The relation among molecular structure of inhibitors, inhibition activity and the effect of polymer particles was discussed. And we also evaluated stabilization ability of G4 by SPR signal of annealing between G4 and telomerase RNA (tR). The results suggested polymer particle led to SPR signal enhancement of interaction between G4 and telomerase inhibitors and the property of inhibitors immobilized on particle was unchanged.

Original language	English
Number of pages	1
Publication status	Published - 2006 Oct 19
Event	55th SPSJ Annual Meeting - Nagoya, Japan Duration: 2006 May 24 → 2006 May 26

Other

Other	55th SPSJ Annual Meeting
Country	Japan
City	Nagoya
Period	06/5/24 → 06/5/26

Keywords

Ethidium bromide
Polymer particle
SPR (surface plasmon resonance)
Telomerase inhibitor
Telomere

ASJC Scopus subject areas

Engineering(all)

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Cite this

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title = "Control of telomerase function on SPR sensor using polymer particles",

abstract = "The interaction of G-quadruplex (G4) DNA with telomerase inhibitors was investigated using SPR sensor. SPR signal was enhanced with polymer particle on which inhibitor was immobilized. The relation among molecular structure of inhibitors, inhibition activity and the effect of polymer particles was discussed. And we also evaluated stabilization ability of G4 by SPR signal of annealing between G4 and telomerase RNA (tR). The results suggested polymer particle led to SPR signal enhancement of interaction between G4 and telomerase inhibitors and the property of inhibitors immobilized on particle was unchanged.",

keywords = "Ethidium bromide, Polymer particle, SPR (surface plasmon resonance), Telomerase inhibitor, Telomere",

author = "Ryuji Hara and Kazunobu Toshima and Haruma Kawaguchi",

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note = "55th SPSJ Annual Meeting ; Conference date: 24-05-2006 Through 26-05-2006",

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T1 - Control of telomerase function on SPR sensor using polymer particles

AU - Hara, Ryuji

AU - Toshima, Kazunobu

AU - Kawaguchi, Haruma

PY - 2006/10/19

Y1 - 2006/10/19

N2 - The interaction of G-quadruplex (G4) DNA with telomerase inhibitors was investigated using SPR sensor. SPR signal was enhanced with polymer particle on which inhibitor was immobilized. The relation among molecular structure of inhibitors, inhibition activity and the effect of polymer particles was discussed. And we also evaluated stabilization ability of G4 by SPR signal of annealing between G4 and telomerase RNA (tR). The results suggested polymer particle led to SPR signal enhancement of interaction between G4 and telomerase inhibitors and the property of inhibitors immobilized on particle was unchanged.

AB - The interaction of G-quadruplex (G4) DNA with telomerase inhibitors was investigated using SPR sensor. SPR signal was enhanced with polymer particle on which inhibitor was immobilized. The relation among molecular structure of inhibitors, inhibition activity and the effect of polymer particles was discussed. And we also evaluated stabilization ability of G4 by SPR signal of annealing between G4 and telomerase RNA (tR). The results suggested polymer particle led to SPR signal enhancement of interaction between G4 and telomerase inhibitors and the property of inhibitors immobilized on particle was unchanged.

KW - Ethidium bromide

KW - Polymer particle

KW - SPR (surface plasmon resonance)

KW - Telomerase inhibitor

KW - Telomere

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T2 - 55th SPSJ Annual Meeting

Y2 - 24 May 2006 through 26 May 2006

ER -