Controlled construction of stable network structure composed of honeycomb-shaped microhydrogels

Masayuki Hayakawa, Satoshi Umeyama, Ken H. Nagai, Hiroaki Onoe, Masahiro Takinoue

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Recently, the construction of models for multicellular systems such as tissues has been attracting great interest. These model systems are expected to reproduce a cell communication network and provide insight into complicated functions in living systems./Such network structures have mainly been modelled using a droplet and a vesicle. However, in the droplet and vesicle network, there are difficulties attributed to structural instabilities due to external stimuli and perturbations. Thus, the fabrication of a network composed of a stable component such as hydrogel is desired. In this article, the construction of a stable network composed of honeycomb-shaped microhydrogels is described. We produced the microhydrogel network using a centrifugal microfluidic technique and a photosensitive polymer. In the network, densely packed honeycomb-shaped microhydrogels were observed. Additionally, we successfully controlled the degree of packing of microhydrogels in the network by changing the centrifugal force. We believe that our stable network will contribute to the study of cell communication in multicellular systems.

Original languageEnglish
Article number38
JournalLife
Volume8
Issue number4
DOIs
Publication statusPublished - 2018 Dec

Keywords

  • Artificial cell/tissue
  • Cell communication
  • Microfluidics
  • Microhydrogel network

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Biochemistry, Genetics and Molecular Biology(all)
  • Space and Planetary Science
  • Palaeontology

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