Controlled dissolution of phenytoin by hybridizing with silica nanoparticles

H. Goto, T. Isobe, M. Senna

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

A sparingly soluble model drug, phenytoin (5,5-diphenyl-hydantoin, denoted as PT), was incorporated during or after hydrolysis and polycondensation of tetra orthoethyl silicate (TEOS) to obtain silica-drug hybrids. We also compare the hybrids obtained by sol-gel process with those obtained by simple adsorption on nonporous silica particles. The initial rate of dissolution in water increases by a factor of 40 with respect to the intact PT by aging silica before drug addition. The IR results show that vC=O in the position 2 of PT and vN-H shift toward the higher wavenumber, showing that intermolecular hydrogen bonds between C=O and N-H are loosened or broken to form new hydrogen bonds between C=O in PT and Si-OH in silica. The dissolution rate of PT is determined by the degree of the breakage of hydrogen bonds between PT molecules and the intensity of the interaction between silica and PT.

Original languageEnglish
Pages (from-to)205-213
Number of pages9
JournalJournal of Nanoparticle Research
Volume1
Issue number2
DOIs
Publication statusPublished - 1999 Jan 1

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Keywords

  • Dissolution rate
  • Hydrogen bond
  • Phenytoin
  • Silica-drug hybrids
  • Sol-gel process
  • Sparingly soluble drug

ASJC Scopus subject areas

  • Bioengineering
  • Chemistry(all)
  • Atomic and Molecular Physics, and Optics
  • Modelling and Simulation
  • Materials Science(all)
  • Condensed Matter Physics

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