Controlled synthesis of 3D multi-compartmental particles with centrifuge-based microdroplet formation from a multi-barrelled capillary

Kazuki Maeda, Hiroaki Onoe, Masahiro Takinoue, Shoji Takeuchi

Research output: Contribution to journalArticle

129 Citations (Scopus)

Abstract

Controlled synthesis of micro multi-compartmental particles using a centrifuge droplet shooting device (CDSD) is reported. Sodium alginate solutions introduced in a multi-barreled capillary form droplets at the capillary orifice under ultrahigh gravity and gelify in a CaCl 2 solution. The size, shape, and compartmentalization of the particles are controlled. Co-encapsulation of Jurkat cells and magnetic colloids into Janus particles is demonstrated. The Janus particles present sensitive reaction toward magnetic fields, while the viability of the encapsulated cells is 91%.

Original languageEnglish
Pages (from-to)1340-1346
Number of pages7
JournalAdvanced Materials
Volume24
Issue number10
DOIs
Publication statusPublished - 2012 Mar 8
Externally publishedYes

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Keywords

  • anisotropic particles
  • cell-encapsulation
  • hydrogels
  • microfabrication
  • microfluidics

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

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