Controlling the drug release rate from biocompatible polymers with micro-patterned diamond-like carbon (DLC) coating

K. Enomoto, T. Hasebe, R. Asakawa, A. Kamijo, Y. Yoshimoto, Tetsuya Suzuki, K. Takahashi, Atsushi Hotta

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

During the past year, we have witnessed the evolution of an intense public controversy regarding late thrombosis following implantation of drug eluting stent (DES) in patients with obstructive coronary artery disease. To overcome the problem, DES should possess sufficient biocompatibility and non-thrombogenicity with a controlled drug release system. A new DES composed of biocompatible polymers coated with antithrombogenic diamond-like carbon (DLC) coating was proposed. In this study, the drug release profile of the newly proposed drug eluting system was thoroughly investigated. Three polymers were selected as base drug-reservoir materials: hydrophilic 2-methacryloyloxyethyl phosphorylcholine (MPC), hydrophobic poly (ethylene-co-vinyl acetate) (EVA) and less hydrophobic polyurethane (PU). The three polymers are currently used or studied for biomedical materials, while MPC and DLC were already confirmed as excellent biocompatible materials with antithrombogenicity. After coating the lattice-like patterned DLC on both polymers containing drug, samples were soaked in 2 ml of medium of phosphate-buffered saline with 10% ethanol. The drug release rate was measured by a spectrophotometer. The percentile cover area of patterned DLC on polymers was varied from 0% (without DLC) to 100% (fully covered). The sample without DLC coating presented an initial burst of the drug release from the polymer matrix, whereas the DLC-coated samples inhibited the initial burst release from polymers within the first five days of the experiments. It was found that the drug eluting profiles could be effectively controlled by changing the cover area of micro-patterned DLC coatings on polymers, which may be applicable to the next-generation DES system that eventually prevents late thrombosis.

Original languageEnglish
Pages (from-to)806-813
Number of pages8
JournalDiamond and Related Materials
Volume19
Issue number7-9
DOIs
Publication statusPublished - 2010 Jul

Fingerprint

Diamond
Diamonds
Polymers
drugs
Carbon
diamonds
coatings
Coatings
Stents
carbon
polymers
Pharmaceutical Preparations
thrombosis
bursts
Spectrophotometers
Polymer matrix
coronary artery disease
Biocompatibility
Biomaterials
Polyurethanes

Keywords

  • Biocompatible polymers
  • Controlled-release
  • Diamond-like carbon
  • Drug eluting stent

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Materials Chemistry
  • Electrical and Electronic Engineering
  • Mechanical Engineering
  • Physics and Astronomy(all)
  • Chemistry(all)

Cite this

Controlling the drug release rate from biocompatible polymers with micro-patterned diamond-like carbon (DLC) coating. / Enomoto, K.; Hasebe, T.; Asakawa, R.; Kamijo, A.; Yoshimoto, Y.; Suzuki, Tetsuya; Takahashi, K.; Hotta, Atsushi.

In: Diamond and Related Materials, Vol. 19, No. 7-9, 07.2010, p. 806-813.

Research output: Contribution to journalArticle

Enomoto, K. ; Hasebe, T. ; Asakawa, R. ; Kamijo, A. ; Yoshimoto, Y. ; Suzuki, Tetsuya ; Takahashi, K. ; Hotta, Atsushi. / Controlling the drug release rate from biocompatible polymers with micro-patterned diamond-like carbon (DLC) coating. In: Diamond and Related Materials. 2010 ; Vol. 19, No. 7-9. pp. 806-813.
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