Convergent total synthesis of epolactaene: Application of bridgehead oxiranyl anion strategy

Kouji Kuramochi, Seigo Nagata, Hideyoshi Itaya, Kenichi Takao, Susumu Kobayashi

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Total synthesis of (+)-epolactaene was accomplished by a convergent approach utilizing the fluoride anion-catalyzed aldol-type reaction of (-)-α-trimethylsilylangelica lactone epoxide with tetraene aldehyde as a key reaction.

Original languageEnglish
Pages (from-to)7371-7374
Number of pages4
JournalTetrahedron Letters
Volume40
Issue number41
DOIs
Publication statusPublished - 1999 Oct 8
Externally publishedYes

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Keywords

  • β-Angelica lactone epoxide
  • Epolactaene
  • Fluoride-catalyzed aldol reaction
  • Oxiranyl anion

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

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