Cooperative action of gut-microbiota-accessible carbohydrates improves host metabolic function

Sawako Tomioka, Natsumi Seki, Yuki Sugiura, Masahiro Akiyama, Jun Uchiyama, Genki Yamaguchi, Kyosuke Yakabe, Ryuta Ejima, Kouya Hattori, Tatsuki Kimizuka, Yumiko Fujimura, Hiroki Sato, Monica Gondo, Satoru Ozaki, Yoshiko Honme, Makoto Suematsu, Ikuo Kimura, Naohiro Inohara, Gabriel Núñez, Koji HaseYungi Kim

Research output: Contribution to journalArticlepeer-review

Abstract

Microbiota-accessible carbohydrates (MACs) exert health-promoting effects, but how each MAC impacts gut microbiota and regulates host physiology remains unclear. Here, we show that L-arabinose and sucrose cooperatively act on gut microbiota and exert anti-obesogenic effects. Specifically, L-arabinose, a monosaccharide that is poorly absorbed in the gut and inhibits intestinal sucrase, suppresses diet-induced obesity in mice in the presence of sucrose. Additionally, the suppressive effect of L-arabinose on adiposity is abrogated in mice lacking the short-chain fatty acid (SCFA) receptors GPR43 and GPR41. Mechanistically, L-arabinose increases the relative abundance of acetate and propionate producers (e.g., Bacteroides), while sucrose enhances SCFA production. Furthermore, L-arabinose and sucrose activate the glycolytic and pentose phosphate pathways of Bacteroides, respectively, indicating that they synergistically promote acetate production through distinct pathways. These findings suggest that each MAC has a unique property and thus may serve as a precision gut-microbiota modulator to promote host homeostasis.

Original languageEnglish
Article number111087
JournalCell Reports
Volume40
Issue number3
DOIs
Publication statusPublished - 2022 Jul 19

Keywords

  • CP: Microbiology
  • gut microbiota
  • L-arabinose
  • metabolism
  • microbiota-accessible carbohydrates
  • obesity
  • short-chain fatty acids
  • sucrose

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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