Corneal epithelial changes after excimer laser photorefractive keratectomy

S. Amano, K. Shimizu, Kazuo Tsubota

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

We used the specular microscope to investigate corneal epithelial changes after excimer laser photorefractive keratectomy. Thirteen patients underwent photorefractive keratectomy on one eye to correct myopia. We observed the central corneal epithelium of each eye at postoperative periods from one to 15 months after photorefractive keratectomy. The fellow eye served as a control. In 11 eyes (85%) the central cornea showed normal epithelial patterns. Two eyes had an abnormal epithelial pattern that included elongated epithelial cells. There was no difference in the mean cell area or coefficient of variation of mean cell area between the treated eyes and the control eyes. These results suggest that permanent destruction of Bowman's membrane caused by photorefractive keratectomy does not affect the morphologic characteristics of the most superficial layer of the corneal epithelium in most eyes. However, the presence of abnormal epithelial cell patterns in two patients should be considered a risk factor for this procedure.

Original languageEnglish
Pages (from-to)441-443
Number of pages3
JournalAmerican Journal of Ophthalmology
Volume115
Issue number4
Publication statusPublished - 1993
Externally publishedYes

Fingerprint

Laser Corneal Surgery
Photorefractive Keratectomy
Excimer Lasers
Corneal Epithelium
Bowman Membrane
Epithelial Cells
Myopia
Postoperative Period
Cornea

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Corneal epithelial changes after excimer laser photorefractive keratectomy. / Amano, S.; Shimizu, K.; Tsubota, Kazuo.

In: American Journal of Ophthalmology, Vol. 115, No. 4, 1993, p. 441-443.

Research output: Contribution to journalArticle

@article{4693a584216e4dbf8c622e96045ae2ea,
title = "Corneal epithelial changes after excimer laser photorefractive keratectomy",
abstract = "We used the specular microscope to investigate corneal epithelial changes after excimer laser photorefractive keratectomy. Thirteen patients underwent photorefractive keratectomy on one eye to correct myopia. We observed the central corneal epithelium of each eye at postoperative periods from one to 15 months after photorefractive keratectomy. The fellow eye served as a control. In 11 eyes (85{\%}) the central cornea showed normal epithelial patterns. Two eyes had an abnormal epithelial pattern that included elongated epithelial cells. There was no difference in the mean cell area or coefficient of variation of mean cell area between the treated eyes and the control eyes. These results suggest that permanent destruction of Bowman's membrane caused by photorefractive keratectomy does not affect the morphologic characteristics of the most superficial layer of the corneal epithelium in most eyes. However, the presence of abnormal epithelial cell patterns in two patients should be considered a risk factor for this procedure.",
author = "S. Amano and K. Shimizu and Kazuo Tsubota",
year = "1993",
language = "English",
volume = "115",
pages = "441--443",
journal = "American Journal of Ophthalmology",
issn = "0002-9394",
publisher = "Elsevier USA",
number = "4",

}

TY - JOUR

T1 - Corneal epithelial changes after excimer laser photorefractive keratectomy

AU - Amano, S.

AU - Shimizu, K.

AU - Tsubota, Kazuo

PY - 1993

Y1 - 1993

N2 - We used the specular microscope to investigate corneal epithelial changes after excimer laser photorefractive keratectomy. Thirteen patients underwent photorefractive keratectomy on one eye to correct myopia. We observed the central corneal epithelium of each eye at postoperative periods from one to 15 months after photorefractive keratectomy. The fellow eye served as a control. In 11 eyes (85%) the central cornea showed normal epithelial patterns. Two eyes had an abnormal epithelial pattern that included elongated epithelial cells. There was no difference in the mean cell area or coefficient of variation of mean cell area between the treated eyes and the control eyes. These results suggest that permanent destruction of Bowman's membrane caused by photorefractive keratectomy does not affect the morphologic characteristics of the most superficial layer of the corneal epithelium in most eyes. However, the presence of abnormal epithelial cell patterns in two patients should be considered a risk factor for this procedure.

AB - We used the specular microscope to investigate corneal epithelial changes after excimer laser photorefractive keratectomy. Thirteen patients underwent photorefractive keratectomy on one eye to correct myopia. We observed the central corneal epithelium of each eye at postoperative periods from one to 15 months after photorefractive keratectomy. The fellow eye served as a control. In 11 eyes (85%) the central cornea showed normal epithelial patterns. Two eyes had an abnormal epithelial pattern that included elongated epithelial cells. There was no difference in the mean cell area or coefficient of variation of mean cell area between the treated eyes and the control eyes. These results suggest that permanent destruction of Bowman's membrane caused by photorefractive keratectomy does not affect the morphologic characteristics of the most superficial layer of the corneal epithelium in most eyes. However, the presence of abnormal epithelial cell patterns in two patients should be considered a risk factor for this procedure.

UR - http://www.scopus.com/inward/record.url?scp=0027469720&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027469720&partnerID=8YFLogxK

M3 - Article

C2 - 8470714

AN - SCOPUS:0027469720

VL - 115

SP - 441

EP - 443

JO - American Journal of Ophthalmology

JF - American Journal of Ophthalmology

SN - 0002-9394

IS - 4

ER -