Coronary artery disease and a functional polymorphism of hTERT

Yumiko Matsubara, Mitsuru Murata, Kiyoaki Watanabe, Ikuo Saito, Koichi Miyaki, Kazuyuki Omae, Mie Ishikawa, Kenichi Matsushita, Shiro Iwanaga, Satoshi Ogawa, Yasuo Ikeda

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Genetic variation, a -1327T/C polymorphism, of human telomerase reverse transcriptase (hTERT) is associated with leukocyte telomere length in healthy subjects, but clinical significances of this functional polymorphism are not clear. Recently, the relationship between the telomere system and coronary artery disease (CAD) was reported. We investigated the association between the -1327T/C polymorphism and (a) susceptibility to CAD and (b) telomere length in CAD patients. In a case-control study, 104 patients confirmed by coronary angiography and 115 age- and sex-matched controls were enrolled. There was a higher frequency of the -1327C/C genotype in CAD patients (51.9%) compared with controls (36.5%, p = 0.0218). Among the 104 CAD patients, leukocyte telomere length in the -1327C/C genotype (7.62 ± 2.19 kb, mean ± SD) was shorter than that in the -1327T/C and -1327T/T genotypes (8.74 ± 2.92, p = 0.0287). These findings suggest that the -1327C/C genotype is a genetic risk factor for CAD and relates to shorter telomere length among CAD patients.

Original languageEnglish
Pages (from-to)669-672
Number of pages4
JournalBiochemical and Biophysical Research Communications
Volume348
Issue number2
DOIs
Publication statusPublished - 2006 Sep 22

Keywords

  • Coronary artery disease
  • Human telomerase reverse transcriptase
  • Polymorphism

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

Fingerprint Dive into the research topics of 'Coronary artery disease and a functional polymorphism of hTERT'. Together they form a unique fingerprint.

  • Cite this

    Matsubara, Y., Murata, M., Watanabe, K., Saito, I., Miyaki, K., Omae, K., Ishikawa, M., Matsushita, K., Iwanaga, S., Ogawa, S., & Ikeda, Y. (2006). Coronary artery disease and a functional polymorphism of hTERT. Biochemical and Biophysical Research Communications, 348(2), 669-672. https://doi.org/10.1016/j.bbrc.2006.07.103