TY - JOUR
T1 - Coronary artery disease and a functional polymorphism of hTERT
AU - Matsubara, Yumiko
AU - Murata, Mitsuru
AU - Watanabe, Kiyoaki
AU - Saito, Ikuo
AU - Miyaki, Koichi
AU - Omae, Kazuyuki
AU - Ishikawa, Mie
AU - Matsushita, Kenichi
AU - Iwanaga, Shiro
AU - Ogawa, Satoshi
AU - Ikeda, Yasuo
PY - 2006/9/22
Y1 - 2006/9/22
N2 - Genetic variation, a -1327T/C polymorphism, of human telomerase reverse transcriptase (hTERT) is associated with leukocyte telomere length in healthy subjects, but clinical significances of this functional polymorphism are not clear. Recently, the relationship between the telomere system and coronary artery disease (CAD) was reported. We investigated the association between the -1327T/C polymorphism and (a) susceptibility to CAD and (b) telomere length in CAD patients. In a case-control study, 104 patients confirmed by coronary angiography and 115 age- and sex-matched controls were enrolled. There was a higher frequency of the -1327C/C genotype in CAD patients (51.9%) compared with controls (36.5%, p = 0.0218). Among the 104 CAD patients, leukocyte telomere length in the -1327C/C genotype (7.62 ± 2.19 kb, mean ± SD) was shorter than that in the -1327T/C and -1327T/T genotypes (8.74 ± 2.92, p = 0.0287). These findings suggest that the -1327C/C genotype is a genetic risk factor for CAD and relates to shorter telomere length among CAD patients.
AB - Genetic variation, a -1327T/C polymorphism, of human telomerase reverse transcriptase (hTERT) is associated with leukocyte telomere length in healthy subjects, but clinical significances of this functional polymorphism are not clear. Recently, the relationship between the telomere system and coronary artery disease (CAD) was reported. We investigated the association between the -1327T/C polymorphism and (a) susceptibility to CAD and (b) telomere length in CAD patients. In a case-control study, 104 patients confirmed by coronary angiography and 115 age- and sex-matched controls were enrolled. There was a higher frequency of the -1327C/C genotype in CAD patients (51.9%) compared with controls (36.5%, p = 0.0218). Among the 104 CAD patients, leukocyte telomere length in the -1327C/C genotype (7.62 ± 2.19 kb, mean ± SD) was shorter than that in the -1327T/C and -1327T/T genotypes (8.74 ± 2.92, p = 0.0287). These findings suggest that the -1327C/C genotype is a genetic risk factor for CAD and relates to shorter telomere length among CAD patients.
KW - Coronary artery disease
KW - Human telomerase reverse transcriptase
KW - Polymorphism
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U2 - 10.1016/j.bbrc.2006.07.103
DO - 10.1016/j.bbrc.2006.07.103
M3 - Article
C2 - 16890917
AN - SCOPUS:33746902732
SN - 0006-291X
VL - 348
SP - 669
EP - 672
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 2
ER -
