Coronary flow characteristics in hypertrophic cardiomyopathy--a study with Doppler catheter

K. Negishi, S. Handa, Y. Asakura, S. Iwanaga, S. Ishikawa, Yumiko Wainai, S. Abe, M. Tani

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

We compared the pattern and reserve of coronary flow in 8 cases of hypertrophic non-obstructive cardiomyopathy (H) with those in 20 cases of chest pain not accompanied by organic heart disease (N). A catheter-tip Doppler velocimeter was positioned in the proximal portion of the left anterior descending (LAD), circumflex (LCX) and right coronary (RCA) arteries. Coronary flow velocity (Vs: systolic peak, Vd: diastolic peak, Vm: mean) was recorded and the area under the velocity curve was divided into systole (* s) and diastole (* d). The time interval between the dicrotic notch in aortic pressure and the peak of diastolic flow velocity was measured (Tpv). Vm was measured before and after intracoronary injection of 6 ml of contrast media, and peak to resting velocity ratio (PRVR) was calculated as an index of coronary flow reserve. Result: In LAD, N showed diastolic predominant coronary flow pattern without backward flow. In H, diastolic predominance was more prominent with systolic backward flow, resulting in decrease in * s/* d(H: 0.07 +/- 0.04, N: 0.25 +/- 0.02, p less than 0.01). In H, Vd (H: 20.1 +/- 2.8, N: 9.2 +/- 1.4 cm/sec, p less than 0.05) and Vm(H: 9.5 +/- 1.3, N: 4.9 +/- 0.7 cm/sec, p less than 0.05) were higher, while PRVR was lower (H: 1.7 +/- 0.1, N: 2.6 +/- 0.1, p less than 0.05). In both N and H, the flow pattern of LCX was diastolic predominant with two peaks (one in systole and the other in diastole).(ABSTRACT TRUNCATED AT 250 WORDS)

Original languageEnglish
Pages (from-to)1021-1027
Number of pages7
JournalRespiration and Circulation
Volume39
Issue number10
Publication statusPublished - 1991 Oct

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Diastole
Systole
Hypertrophic Cardiomyopathy
Catheters
Chest Pain
Contrast Media
Area Under Curve
Heart Diseases
Coronary Vessels
Arterial Pressure
Injections

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pulmonary and Respiratory Medicine

Cite this

Negishi, K., Handa, S., Asakura, Y., Iwanaga, S., Ishikawa, S., Wainai, Y., ... Tani, M. (1991). Coronary flow characteristics in hypertrophic cardiomyopathy--a study with Doppler catheter. Respiration and Circulation, 39(10), 1021-1027.

Coronary flow characteristics in hypertrophic cardiomyopathy--a study with Doppler catheter. / Negishi, K.; Handa, S.; Asakura, Y.; Iwanaga, S.; Ishikawa, S.; Wainai, Yumiko; Abe, S.; Tani, M.

In: Respiration and Circulation, Vol. 39, No. 10, 10.1991, p. 1021-1027.

Research output: Contribution to journalArticle

Negishi, K, Handa, S, Asakura, Y, Iwanaga, S, Ishikawa, S, Wainai, Y, Abe, S & Tani, M 1991, 'Coronary flow characteristics in hypertrophic cardiomyopathy--a study with Doppler catheter', Respiration and Circulation, vol. 39, no. 10, pp. 1021-1027.
Negishi K, Handa S, Asakura Y, Iwanaga S, Ishikawa S, Wainai Y et al. Coronary flow characteristics in hypertrophic cardiomyopathy--a study with Doppler catheter. Respiration and Circulation. 1991 Oct;39(10):1021-1027.
Negishi, K. ; Handa, S. ; Asakura, Y. ; Iwanaga, S. ; Ishikawa, S. ; Wainai, Yumiko ; Abe, S. ; Tani, M. / Coronary flow characteristics in hypertrophic cardiomyopathy--a study with Doppler catheter. In: Respiration and Circulation. 1991 ; Vol. 39, No. 10. pp. 1021-1027.
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AU - Negishi, K.

AU - Handa, S.

AU - Asakura, Y.

AU - Iwanaga, S.

AU - Ishikawa, S.

AU - Wainai, Yumiko

AU - Abe, S.

AU - Tani, M.

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N2 - We compared the pattern and reserve of coronary flow in 8 cases of hypertrophic non-obstructive cardiomyopathy (H) with those in 20 cases of chest pain not accompanied by organic heart disease (N). A catheter-tip Doppler velocimeter was positioned in the proximal portion of the left anterior descending (LAD), circumflex (LCX) and right coronary (RCA) arteries. Coronary flow velocity (Vs: systolic peak, Vd: diastolic peak, Vm: mean) was recorded and the area under the velocity curve was divided into systole (* s) and diastole (* d). The time interval between the dicrotic notch in aortic pressure and the peak of diastolic flow velocity was measured (Tpv). Vm was measured before and after intracoronary injection of 6 ml of contrast media, and peak to resting velocity ratio (PRVR) was calculated as an index of coronary flow reserve. Result: In LAD, N showed diastolic predominant coronary flow pattern without backward flow. In H, diastolic predominance was more prominent with systolic backward flow, resulting in decrease in * s/* d(H: 0.07 +/- 0.04, N: 0.25 +/- 0.02, p less than 0.01). In H, Vd (H: 20.1 +/- 2.8, N: 9.2 +/- 1.4 cm/sec, p less than 0.05) and Vm(H: 9.5 +/- 1.3, N: 4.9 +/- 0.7 cm/sec, p less than 0.05) were higher, while PRVR was lower (H: 1.7 +/- 0.1, N: 2.6 +/- 0.1, p less than 0.05). In both N and H, the flow pattern of LCX was diastolic predominant with two peaks (one in systole and the other in diastole).(ABSTRACT TRUNCATED AT 250 WORDS)

AB - We compared the pattern and reserve of coronary flow in 8 cases of hypertrophic non-obstructive cardiomyopathy (H) with those in 20 cases of chest pain not accompanied by organic heart disease (N). A catheter-tip Doppler velocimeter was positioned in the proximal portion of the left anterior descending (LAD), circumflex (LCX) and right coronary (RCA) arteries. Coronary flow velocity (Vs: systolic peak, Vd: diastolic peak, Vm: mean) was recorded and the area under the velocity curve was divided into systole (* s) and diastole (* d). The time interval between the dicrotic notch in aortic pressure and the peak of diastolic flow velocity was measured (Tpv). Vm was measured before and after intracoronary injection of 6 ml of contrast media, and peak to resting velocity ratio (PRVR) was calculated as an index of coronary flow reserve. Result: In LAD, N showed diastolic predominant coronary flow pattern without backward flow. In H, diastolic predominance was more prominent with systolic backward flow, resulting in decrease in * s/* d(H: 0.07 +/- 0.04, N: 0.25 +/- 0.02, p less than 0.01). In H, Vd (H: 20.1 +/- 2.8, N: 9.2 +/- 1.4 cm/sec, p less than 0.05) and Vm(H: 9.5 +/- 1.3, N: 4.9 +/- 0.7 cm/sec, p less than 0.05) were higher, while PRVR was lower (H: 1.7 +/- 0.1, N: 2.6 +/- 0.1, p less than 0.05). In both N and H, the flow pattern of LCX was diastolic predominant with two peaks (one in systole and the other in diastole).(ABSTRACT TRUNCATED AT 250 WORDS)

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