Correlation among body composition and metabolic regulation in a male mouse model of cushing’s syndrome

Masaaki Uehara, Hiroki Yamazaki, Noritada Yoshikawa, Akiko Kuribara-Souta, Hirotoshi Tanaka

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Glucocorticoids play a critical role in the regulation of homeostasis, including metabolism. In patients with Cushing’s syndrome, chronic glucocorticoid excess disrupts physiological internal milieu, resulting in central obesity, muscle atrophy, fatty liver, and insulin resistance. However, the relationship among various metabolic effects of glucocorticoids remains unknown. In the present study, we studied a male mouse model of Cushing’ s syndrome and indicated that glucocorticoid excess alters metabolic phenotype and body composition involving possible communication among skeletal muscle, liver, and adipose tissue.

Original languageEnglish
Pages (from-to)21-30
Number of pages10
JournalEndocrine journal
Volume67
Issue number1
DOIs
Publication statusPublished - 2020
Externally publishedYes

Keywords

  • Body composition
  • Cushing’s syndrome
  • Glucocorticoid
  • Inter-organ communication
  • Metabolism

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Fingerprint

Dive into the research topics of 'Correlation among body composition and metabolic regulation in a male mouse model of cushing’s syndrome'. Together they form a unique fingerprint.

Cite this