TY - JOUR
T1 - Correlation among body composition and metabolic regulation in a male mouse model of cushing’s syndrome
AU - Uehara, Masaaki
AU - Yamazaki, Hiroki
AU - Yoshikawa, Noritada
AU - Kuribara-Souta, Akiko
AU - Tanaka, Hirotoshi
N1 - Funding Information:
Fukuyama (Division of Virology, Department of Micro-? biology and Immunology, Institute of Medical Science, The University of Tokyo) for technical support for CT analysis. We also thank all members of Tanaka Labora-? tory for helpful comments. This work was supported by JSPS KAK?NHI Grant Numbers JP16H05330, JP16K09230, and JP17K16158 (to H.T., N.Y., and H.Y., respectively).
Publisher Copyright:
© The Japan Endocrine Society.
PY - 2020
Y1 - 2020
N2 - Glucocorticoids play a critical role in the regulation of homeostasis, including metabolism. In patients with Cushing’s syndrome, chronic glucocorticoid excess disrupts physiological internal milieu, resulting in central obesity, muscle atrophy, fatty liver, and insulin resistance. However, the relationship among various metabolic effects of glucocorticoids remains unknown. In the present study, we studied a male mouse model of Cushing’ s syndrome and indicated that glucocorticoid excess alters metabolic phenotype and body composition involving possible communication among skeletal muscle, liver, and adipose tissue.
AB - Glucocorticoids play a critical role in the regulation of homeostasis, including metabolism. In patients with Cushing’s syndrome, chronic glucocorticoid excess disrupts physiological internal milieu, resulting in central obesity, muscle atrophy, fatty liver, and insulin resistance. However, the relationship among various metabolic effects of glucocorticoids remains unknown. In the present study, we studied a male mouse model of Cushing’ s syndrome and indicated that glucocorticoid excess alters metabolic phenotype and body composition involving possible communication among skeletal muscle, liver, and adipose tissue.
KW - Body composition
KW - Cushing’s syndrome
KW - Glucocorticoid
KW - Inter-organ communication
KW - Metabolism
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U2 - 10.1507/endocrj.EJ19-0205
DO - 10.1507/endocrj.EJ19-0205
M3 - Article
C2 - 31495810
AN - SCOPUS:85078693633
SN - 0918-8959
VL - 67
SP - 21
EP - 30
JO - Endocrine Journal
JF - Endocrine Journal
IS - 1
ER -
